Show simple item record

dc.contributor.authorSing, Charles E.
dc.contributor.authorSelvidge, Jennifer G.
dc.contributor.authorAlexander-Katz, Alfredo
dc.contributor.authorSelvidge, Jennifer G.
dc.date.accessioned2014-11-20T14:19:01Z
dc.date.available2014-11-20T14:19:01Z
dc.date.issued2013-08
dc.date.submitted2013-02
dc.identifier.issn00063495
dc.identifier.issn1542-0086
dc.identifier.urihttp://hdl.handle.net/1721.1/91635
dc.description.abstractVon Willebrand factor (vWF) adsorbs and immobilizes platelets at sites of injury under high-shear-rate conditions. It has been recently demonstrated that single vWF molecules only adsorb significantly to collagen above a threshold shear, and here we explain such counterintuitive behavior using a coarse-grained simulation and a phenomenological theory. We find that shear-induced adsorption only occurs if the vWF-surface bonds are slip-resistant such that force-induced unbinding is suppressed, which occurs in many biological bonds (i.e., catch bonds). Our results quantitatively match experimental observations and may be important to understand the activation and mechanical regulation of vWF activity during blood clotting.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.bpj.2013.08.006en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleVon Willlebrand Adhesion to Surfaces at High Shear Rates Is Controlled by Long-Lived Bondsen_US
dc.typeArticleen_US
dc.identifier.citationSing, Charles E., Jennifer G. Selvidge, and Alfredo Alexander-Katz. “Von Willlebrand Adhesion to Surfaces at High Shear Rates Is Controlled by Long-Lived Bonds.” Biophysical Journal 105.6 (2013): 1475–1481.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.mitauthorSelvidge, Jennifer G.en_US
dc.contributor.mitauthorAlexander-Katz, Alfredoen_US
dc.relation.journalBiophysical Journalen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSing, Charles E.; Selvidge, Jennifer G.; Alexander-Katz, Alfredoen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5554-1283
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record