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The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

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dc.contributor.author Govindarajan, Arvind
dc.contributor.author Israely, Inbal
dc.contributor.author Tonegawa, Susumu
dc.contributor.author Huang, Shu Ying
dc.date.accessioned 2014-12-16T18:36:38Z
dc.date.available 2014-12-16T18:36:38Z
dc.date.issued 2011-01
dc.date.submitted 2010-10
dc.identifier.issn 08966273
dc.identifier.issn 1097-4199
dc.identifier.uri http://hdl.handle.net/1721.1/92335
dc.description.abstract The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage. en_US
dc.description.sponsorship National Institutes of Health (U.S.) en_US
dc.description.sponsorship Howard Hughes Medical Institute en_US
dc.description.sponsorship RIKEN en_US
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.relation.isversionof http://dx.doi.org/10.1016/j.neuron.2010.12.008 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source Elsevier en_US
dc.title The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP en_US
dc.type Article en_US
dc.identifier.citation Govindarajan, Arvind, Inbal Israely, Shu-Ying Huang, and Susumu Tonegawa. “The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP.” Neuron 69, no. 1 (January 2011): 132–146. © 2011 Elsevier Inc. en_US
dc.contributor.department Picower Institute for Learning and Memory en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences en_US
dc.contributor.department RIKEN-MIT Center for Neural Circuit Genetics en_US
dc.contributor.mitauthor Govindarajan, Arvind en_US
dc.contributor.mitauthor Huang, Shu Ying en_US
dc.contributor.mitauthor Israely, Inbal en_US
dc.contributor.mitauthor Tonegawa, Susumu en_US
dc.relation.journal Neuron en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Govindarajan, Arvind; Israely, Inbal; Huang, Shu-Ying; Tonegawa, Susumu en_US
dc.identifier.orcid https://orcid.org/0000-0003-2839-8228
dc.identifier.orcid https://orcid.org/0000-0001-7234-6359
dc.identifier.orcid https://orcid.org/0000-0003-3984-6057


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