Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates

Author(s)
Teverovskiy, Georgiy; Park, Nathaniel Hamilton; Buchwald, Stephen Leffler
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Abstract
A new air-stable nickel precatalyst for C–N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C–N bond formation to include both a wide range of aryl and heteroaryl electrophiles and aryl, heteroaryl, and alkylamines. The catalyst system is also compatible with a weak base, allowing the amination of substrates containing base-sensitive functional groups.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/94344
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Park, Nathaniel H., Georgiy Teverovskiy, and Stephen L. Buchwald. “Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates.” Org. Lett. 16, no. 1 (January 3, 2014): 220–223.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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