Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Author(s)
Sengupta, Shomit; Peterson, Timothy Richard; Sabatini, David
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The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeostatic systems governed by mTOR and therefore require appropriate stress responses to allow cells to continue to function. Stress can manifest from an excess or lack of upstream signals or as a result of genetic perturbations in upstream effectors of the pathway. mTOR nucleates two large protein complexes that are important nodes in the pathways that help buffer cells from stresses, and are implicated in the progression of stress-associated phenotypes and diseases, such as aging, tumorigenesis, and diabetes. This review focuses on the key components of the mTOR complex 1 pathway and on how various stresses impinge upon them.
Date issued
2010-10Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research; Koch Institute for Integrative Cancer Research at MITJournal
Molecular Cell
Publisher
Elsevier B.V.
Citation
Sengupta, Shomit, Timothy R. Peterson, and David M. Sabatini. “Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress.” Molecular Cell 40, no. 2 (October 2010): 310–322. © 2010 Elsevier Inc.
Version: Final published version
ISSN
10972765