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TALEN-mediated editing of the mouse Y chromosome

dc.contributor.authorWang, Haoyi
dc.contributor.authorHu, Yueh-Chiang
dc.contributor.authorMarkoulaki, Styliani
dc.contributor.authorWelstead, G Grant
dc.contributor.authorShivalila, Chikdu Shakti
dc.contributor.authorPyntikova, Tatyana
dc.contributor.authorDadon, Daniel Benjamin
dc.contributor.authorVoytas, Daniel F.
dc.contributor.authorBogdanove, Adam J.
dc.contributor.authorJaenisch, Rudolf
dc.contributor.authorWelstead, G. Grant
dc.contributor.authorCheng, Albert Wu
dc.contributor.authorPage, David C
dc.date.accessioned2015-04-13T16:08:11Z
dc.date.available2015-04-13T16:08:11Z
dc.date.issued2013-05
dc.date.submitted2013-01
dc.identifier.issn1087-0156
dc.identifier.issn1546-1696
dc.identifier.urihttp://hdl.handle.net/1721.1/96532
dc.description.abstractThe functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes—Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (US NIH grant R01-HG000257)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (US NIH grant R01-CA084198)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (US NIH grant R37-HD045022)en_US
dc.description.sponsorshipCroucher Foundation (Scholarship)en_US
dc.description.sponsorshipHoward Hughes Medical Institute (Investigator)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nbt.2595en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleTALEN-mediated editing of the mouse Y chromosomeen_US
dc.typeArticleen_US
dc.identifier.citationWang, Haoyi, Yueh-Chiang Hu, Styliani Markoulaki, G Grant Welstead, Albert W Cheng, Chikdu S Shivalila, Tatyana Pyntikova, et al. “TALEN-Mediated Editing of the Mouse Y Chromosome.” Nature Biotechnology 31, no. 6 (May 12, 2013): 530–532.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Computational and Systems Biology Programen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorWang, Haoyien_US
dc.contributor.mitauthorHu, Yueh-Chiangen_US
dc.contributor.mitauthorMarkoulaki, Stylianien_US
dc.contributor.mitauthorWelstead, G. Granten_US
dc.contributor.mitauthorCheng, Albert W.en_US
dc.contributor.mitauthorShivalila, Chikdu Shaktien_US
dc.contributor.mitauthorPyntikova, Tatyanaen_US
dc.contributor.mitauthorDadon, Daniel Benjaminen_US
dc.contributor.mitauthorPage, David C.en_US
dc.contributor.mitauthorJaenisch, Rudolfen_US
dc.relation.journalNature Biotechnologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWang, Haoyi; Hu, Yueh-Chiang; Markoulaki, Styliani; Welstead, G Grant; Cheng, Albert W; Shivalila, Chikdu S; Pyntikova, Tatyana; Dadon, Daniel B; Voytas, Daniel F; Bogdanove, Adam J; Page, David C; Jaenisch, Rudolfen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9920-3411
dc.identifier.orcidhttps://orcid.org/0000-0002-7256-3158
dc.identifier.orcidhttps://orcid.org/0000-0002-2905-0306
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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