Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides

Author(s)
Su, Mingjuan; Hoshiya, Naoyuki; Buchwald, Stephen Leffler
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Abstract
An efficient method for the palladium-catalyzed amination of unprotected bromoimidazoles and bromopyrazoles is presented. The transformation is facilitated by the use of our newly developed Pd precatalyst based on the bulky biarylphosphine ligand tBuBrettPhos (L4). The mild reaction conditions employed allow for the preparation of a broad scope of aminoimidazoles and aminopyrazoles in moderate to excellent yields.
Date issued
2014-01
URI
http://hdl.handle.net/1721.1/96743
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Su, Mingjuan, Naoyuki Hoshiya, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides.” Org. Lett. 16, no. 3 (February 7, 2014): 832–835. © 2014 American Chemical Society
Version: Final published version
ISSN
1523-7060
1523-7052
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