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dc.contributor.authorReddien, Peter
dc.date.accessioned2015-10-06T19:13:54Z
dc.date.available2015-10-06T19:13:54Z
dc.date.issued2011-06
dc.identifier.issn01689525
dc.identifier.urihttp://hdl.handle.net/1721.1/99169
dc.description.abstractPlanarians are flatworms that constitutively maintain adult tissues through cell turnover and can regenerate entire organisms from tiny body fragments. In addition to requiring new cells (from neoblasts), these feats require mechanisms that specify tissue identity in the adult. Crucial roles for Wnt and BMP signaling in the regeneration and maintenance of the body axes have been uncovered, among other regulatory factors. Available data indicate that genes involved in positional identity regulation at key embryonic stages in other animals display persisting regionalized expression in adult planarians. These expression patterns suggest that a constitutively active gene expression map exists for the maintenance of the planarian body. Planarians thus present a fertile ground for the identification of factors regulating the regionalization of the metazoan body plan and for the study of the attributes of these factors that can lead to the maintenance and regeneration of adult tissues.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01GM080639)en_US
dc.description.sponsorshipAmerican Cancer Society (RSG-07-180-01-DDC)en_US
dc.description.sponsorshipW. M. Keck Foundationen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.tig.2011.04.004en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleConstitutive gene expression and the specification of tissue identity in adult planarian biologyen_US
dc.typeArticleen_US
dc.identifier.citationReddien, Peter W. “Constitutive Gene Expression and the Specification of Tissue Identity in Adult Planarian Biology.” Trends in Genetics 27, no. 7 (July 2011): 277–285.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorReddien, Peteren_US
dc.relation.journalTrends in Geneticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsReddien, Peter W.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5569-333X
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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