Thalamic reticular nucleus induces fast and local modulation of arousal state
Name
eLife.08760.full.pdf
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3.29 MB
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Adobe PDF
Checksum (MD5)
d5bb4a55edb98c8ba023fc2bd930318d
Author(s)
Voigts, Jakob
Lewis, Laura D.
Flores Plaza, Francisco Javier
Schmitt, Lukas I.
Wilson, Matthew A.
Halassa, Michael M.
Brown, Emery N.
Date Issued
October 2015
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Lewis, Laura D, Jakob Voigts, Francisco J Flores, Lukas I Schmitt, Matthew A Wilson, Michael M Halassa, and Emery N Brown. “Thalamic Reticular Nucleus Induces Fast and Local Modulation of Arousal State.” eLife 4 (October 13, 2015).
Version
Author's final manuscript
Abstract
During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence. Slow waves are locally regulated, and local slow wave dynamics are important for memory, cognition, and behaviour. While several brainstem structures for controlling global sleep states have now been well characterized, a mechanism underlying fast and local modulation of cortical slow waves has not been identified. Here, using optogenetics and whole cortex electrophysiology, we show that local tonic activation of thalamic reticular nucleus (TRN) rapidly induces slow wave activity in a spatially restricted region of cortex. These slow waves resemble those seen in sleep, as cortical units undergo periods of silence phase-locked to the slow wave. Furthermore, animals exhibit behavioural changes consistent with a decrease in arousal state during TRN stimulation. We conclude that TRN can induce rapid modulation of local cortical state.
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.7554/eLife.08760
