Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
| dc.contributor.author | Waterhouse, Robert | |
| dc.contributor.author | Chan, Clara Sophia | |
| dc.contributor.author | Jungreis, Irwin | |
| dc.contributor.author | Novoa Pardo, Eva Maria | |
| dc.contributor.author | Wu, Yi-Chieh | |
| dc.contributor.author | Kellis, Manolis | |
| dc.date.accessioned | 2016-01-08T01:26:35Z | |
| dc.date.available | 2016-01-08T01:26:35Z | |
| dc.date.issued | 2014-11 | |
| dc.date.submitted | 2014-07 | |
| dc.identifier.issn | 0036-8075 | |
| dc.identifier.issn | 1095-9203 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/100767 | |
| dc.description.abstract | Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts. | en_US |
| dc.description.sponsorship | National Human Genome Research Institute (U.S.) (U54 HG003067) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1126/science.1258522 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Neafsey, D. E., R. M. Waterhouse, M. R. Abai, S. S. Aganezov, M. A. Alekseyev, J. E. Allen, J. Amon, et al. “Highly Evolvable Malaria Vectors: The Genomes of 16 Anopheles Mosquitoes.” Science 347, no. 6217 (November 27, 2014): 1258522–1258522. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
| dc.contributor.mitauthor | Waterhouse, Robert | en_US |
| dc.contributor.mitauthor | Chan, Clara Sophia | en_US |
| dc.contributor.mitauthor | Jungreis, Irwin | en_US |
| dc.contributor.mitauthor | Novoa Pardo, Eva Maria | en_US |
| dc.contributor.mitauthor | Wu, Yi-Chieh | en_US |
| dc.contributor.mitauthor | Kellis, Manolis | en_US |
| dc.relation.journal | Science | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Neafsey, D. E.; Waterhouse, R. M.; Abai, M. R.; Aganezov, S. S.; Alekseyev, M. A.; Allen, J. E.; Amon, J.; Arca, B.; Arensburger, P.; Artemov, G.; Assour, L. A.; Basseri, H.; Berlin, A.; Birren, B. W.; Blandin, S. A.; Brockman, A. I.; Burkot, T. R.; Burt, A.; Chan, C. S.; Chauve, C.; Chiu, J. C.; Christensen, M.; Costantini, C.; Davidson, V. L. M.; Deligianni, E.; Dottorini, T.; Dritsou, V.; Gabriel, S. B.; Guelbeogo, W. M.; Hall, A. B.; Han, M. V.; Hlaing, T.; Hughes, D. S. T.; Jenkins, A. M.; Jiang, X.; Jungreis, I.; Kakani, E. G.; Kamali, M.; Kemppainen, P.; Kennedy, R. C.; Kirmitzoglou, I. K.; Koekemoer, L. L.; Laban, N.; Langridge, N.; Lawniczak, M. K. N.; Lirakis, M.; Lobo, N. F.; Lowy, E.; MacCallum, R. M.; Mao, C.; Maslen, G.; Mbogo, C.; McCarthy, J.; Michel, K.; Mitchell, S. N.; Moore, W.; Murphy, K. A.; Naumenko, A. N.; Nolan, T.; Novoa, E. M.; O'Loughlin, S.; Oringanje, C.; Oshaghi, M. A.; Pakpour, N.; Papathanos, P. A.; Peery, A. N.; Povelones, M.; Prakash, A.; Price, D. P.; Rajaraman, A.; Reimer, L. J.; Rinker, D. C.; Rokas, A.; Russell, T. L.; Sagnon, N.; Sharakhova, M. V.; Shea, T.; Simao, F. A.; Simard, F.; Slotman, M. A.; Somboon, P.; Stegniy, V.; Struchiner, C. J.; Thomas, G. W. C.; Tojo, M.; Topalis, P.; Tubio, J. M. C.; Unger, M. F.; Vontas, J.; Walton, C.; Wilding, C. S.; Willis, J. H.; Wu, Y.-C.; Yan, G.; Zdobnov, E. M.; Zhou, X.; Catteruccia, F.; Christophides, G. K.; Collins, F. H.; Cornman, R. S.; Crisanti, A.; Donnelly, M. J.; Emrich, S. J.; Fontaine, M. C.; Gelbart, W.; Hahn, M. W.; Hansen, I. A.; Howell, P. I.; Kafatos, F. C.; Kellis, M.; Lawson, D.; Louis, C.; Luckhart, S.; Muskavitch, M. A. T.; Ribeiro, J. M.; Riehle, M. A.; Sharakhov, I. V.; Tu, Z.; Zwiebel, L. J.; Besansky, N. J. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-7852-4328 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-9367-6311 | |
| dspace.mitauthor.error | true | |
| mit.license | PUBLISHER_POLICY | en_US |
