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dc.contributor.authorChen, Allen Y.
dc.contributor.authorDeng, Zhengtao
dc.contributor.authorBillings, Amanda N.
dc.contributor.authorSeker, Urartu O. S.
dc.contributor.authorLu, Michelle Y.
dc.contributor.authorCitorik, Robert James
dc.contributor.authorZakeri, Bijan
dc.contributor.authorLu, Timothy K.
dc.date.accessioned2016-01-14T18:19:09Z
dc.date.available2016-01-14T18:19:09Z
dc.date.issued2014-03
dc.date.submitted2013-06
dc.identifier.issn1476-1122
dc.identifier.issn1476-4660
dc.identifier.urihttp://hdl.handle.net/1721.1/100838
dc.description.abstractMany natural biological systems—such as biofilms, shells and skeletal tissues—are able to assemble multifunctional and environmentally responsive multiscale assemblies of living and non-living components. Here, by using inducible genetic circuits and cellular communication circuits to regulate Escherichia coli curli amyloid production, we show that E. coli cells can organize self-assembling amyloid fibrils across multiple length scales, producing amyloid-based materials that are either externally controllable or undergo autonomous patterning. We also interfaced curli fibrils with inorganic materials, such as gold nanoparticles (AuNPs) and quantum dots (QDs), and used these capabilities to create an environmentally responsive biofilm-based electrical switch, produce gold nanowires and nanorods, co-localize AuNPs with CdTe/CdS QDs to modulate QD fluorescence lifetimes, and nucleate the formation of fluorescent ZnS QDs. This work lays a foundation for synthesizing, patterning, and controlling functional composite materials with engineered cells.en_US
dc.description.sponsorshipUnited States. Office of Naval Researchen_US
dc.description.sponsorshipUnited States. Army Research Officeen_US
dc.description.sponsorshipNational Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (Award DMR-0819762)en_US
dc.description.sponsorshipHertz Foundationen_US
dc.description.sponsorshipUnited States. Dept. of Defenseen_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Medical Scientist Training Program (Grant T32GM007753)en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (Training Grant in Toxicology 5 T32 ES7020-37)en_US
dc.description.sponsorshipPresidential Early Career Award for Scientists and Engineersen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (New Innovator Award 1DP2OD008435)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nmat3912en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleSynthesis and patterning of tunable multiscale materials with engineered cellsen_US
dc.typeArticleen_US
dc.identifier.citationChen, Allen Y., Zhengtao Deng, Amanda N. Billings, Urartu O. S. Seker, Michelle Y. Lu, Robert J. Citorik, Bijan Zakeri, and Timothy K. Lu. “Synthesis and Patterning of Tunable Multiscale Materials with Engineered Cells.” Nat Mater 13, no. 5 (March 23, 2014): 515–523.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Microbiology Graduate Programen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Synthetic Biology Centeren_US
dc.contributor.mitauthorChen, Allen Y.en_US
dc.contributor.mitauthorDeng, Zhengtaoen_US
dc.contributor.mitauthorSeker, Urartu O. S.en_US
dc.contributor.mitauthorLu, Michelle Y.en_US
dc.contributor.mitauthorCitorik, Robert Jamesen_US
dc.contributor.mitauthorZakeri, Bijanen_US
dc.contributor.mitauthorLu, Timothy K.en_US
dc.contributor.mitauthorBillings, Amanda N.en_US
dc.relation.journalNature Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChen, Allen Y.; Deng, Zhengtao; Billings, Amanda N.; Seker, Urartu O. S.; Lu, Michelle Y.; Citorik, Robert J.; Zakeri, Bijan; Lu, Timothy K.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-9999-6690
dc.identifier.orcidhttps://orcid.org/0000-0003-0929-0393
dc.identifier.orcidhttps://orcid.org/0000-0002-4639-7248
dc.identifier.orcidhttps://orcid.org/0000-0002-6397-5417
dc.identifier.orcidhttps://orcid.org/0000-0002-8428-8982
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US


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