Predicting specificity in bZIP coiled-coil protein interactions
Author(s)Singh, Mona; Keating, Amy E.; Fong, Jessica H.
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We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.
DepartmentMassachusetts Institute of Technology. Department of Biology
Fong, Jessica H, Amy E Keating, and Mona Singh. "Predicting specificity in bZIP coiled-coil protein interactions." Genome Biology 5, no. 2 (2004): R11.
Final published version