Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells
Author(s)Sun, Chen; Kitamura, Takashi; Yamamoto, Jun; Martin, Jared; Kitch, Lacey J.; Schnitzer, Mark J.; Tonegawa, Susumu; Pignatelli di Spinazzola, Michele; ... Show more Show less
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Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell type-specific Ca[superscript 2+] imaging in freely exploring mice using cellular markers and a miniature head-mounted fluorescence microscope. We found that both oceans and islands contain grid cells in similar proportions, but island cell activity, including activity in a proportion of grid cells, is significantly more speed modulated than ocean cell activity. We speculate that this differential property reflects island cells’ and ocean cells’ contribution to different downstream functions: island cells may contribute more to spatial path integration, whereas ocean cells may facilitate contextual representation in downstream circuits.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory; RIKEN-MIT Center for Neural Circuit Genetics
Proceedings of the National Academy of Sciences
National Academy of Sciences (U.S.)
Sun, Chen, Takashi Kitamura, Jun Yamamoto, Jared Martin, Michele Pignatelli, Lacey J. Kitch, Mark J. Schnitzer, and Susumu Tonegawa. “Distinct Speed Dependence of Entorhinal Island and Ocean Cells, Including Respective Grid Cells.” Proc Natl Acad Sci USA 112, no. 30 (July 13, 2015): 9466–9471.
Final published version