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dc.contributor.authorTibbitt, Mark W.
dc.contributor.authorMattix, Bradley A.
dc.contributor.authorVeiseh, Omid
dc.contributor.authorLanger, Robert
dc.contributor.authorAppel, Eric Andrew
dc.contributor.authorWebber, Matthew
dc.date.accessioned2016-02-17T21:35:55Z
dc.date.available2016-02-17T21:35:55Z
dc.date.issued2015-02
dc.date.submitted2014-04
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/101204
dc.description.abstractMouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly utilized as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer–nanoparticle (NP) interactions. Biopolymer derivatives are linked together by selective adsorption to NPs. The transient and reversible interactions between biopolymers and NPs enable flow under applied shear stress, followed by rapid self-healing when the stress is relaxed. We develop a physical description of polymer–NP gel formation that is utilized to design biocompatible gels for drug delivery. Owing to the hierarchical structure of the gel, both hydrophilic and hydrophobic drugs can be entrapped and delivered with differential release profiles, both in vitro and in vivo. The work introduces a facile and generalizable class of mouldable hydrogels amenable to a range of biomedical and industrial applications.en_US
dc.description.sponsorshipWellcome Trust-MIT Postdoctoral Fellowshipen_US
dc.description.sponsorshipMisrock Foundation (Cancer Nanotechnology Postdoctoral Fellowship)en_US
dc.description.sponsorshipUnited States. Dept. of Defense. Congressionally Directed Medical Research Programs (Postdoctoral Fellowship Award W81XWH-13-1-0215)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH-R01 DE016516)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms7295en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleSelf-assembled hydrogels utilizing polymer–nanoparticle interactionsen_US
dc.typeArticleen_US
dc.identifier.citationAppel, Eric A., Mark W. Tibbitt, Matthew J. Webber, Bradley A. Mattix, Omid Veiseh, and Robert Langer. “Self-Assembled Hydrogels Utilizing Polymer–nanoparticle Interactions.” Nat Comms 6 (February 19, 2015): 6295.en_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.mitauthorAppel, Eric Andrewen_US
dc.contributor.mitauthorTibbitt, Mark W.en_US
dc.contributor.mitauthorWebber, Matthewen_US
dc.contributor.mitauthorMattix, Bradley A.en_US
dc.contributor.mitauthorVeiseh, Omiden_US
dc.contributor.mitauthorLanger, Roberten_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsAppel, Eric A.; Tibbitt, Mark W.; Webber, Matthew J.; Mattix, Bradley A.; Veiseh, Omid; Langer, Roberten_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4917-7187
dc.identifier.orcidhttps://orcid.org/0000-0003-0624-3532
dc.identifier.orcidhttps://orcid.org/0000-0002-2301-7126
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
mit.licenseOPEN_ACCESS_POLICYen_US


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