dc.contributor.author | Hartley, Meredith D. | |
dc.contributor.author | Imperiali, Barbara | |
dc.date.accessioned | 2016-02-24T16:58:30Z | |
dc.date.available | 2016-02-24T16:58:30Z | |
dc.date.issued | 2011-11 | |
dc.date.submitted | 2011-10 | |
dc.identifier.issn | 00039861 | |
dc.identifier.issn | 1096-0384 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/101254 | |
dc.description.abstract | Long-chain polyprenols and polyprenyl-phosphates are ubiquitous and essential components of cellular membranes throughout all domains of life. Polyprenyl-phosphates, which include undecaprenyl-phosphate in bacteria and the dolichyl-phosphates in archaea and eukaryotes, serve as specific membrane-bound carriers in glycan biosynthetic pathways responsible for the production of cellular structures such as N-linked protein glycans and bacterial peptidoglycan. Polyprenyl-phosphates are the only form of polyprenols with a biochemically-defined role; however, unmodified or esterified polyprenols often comprise significant percentages of the cellular polyprenol pool. The strong evolutionary conservation of unmodified polyprenols as membrane constituents and polyprenyl-phosphates as preferred glycan carriers in biosynthetic pathways is poorly understood. This review surveys the available research to explore why unmodified polyprenols have been conserved in evolution and why polyprenyl-phosphates are universally and specifically utilized for membrane-bound glycan assembly. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (GM039334) | en_US |
dc.description.sponsorship | American Chemical Society. Medicinal Chemistry Division (Graduate Fellowship) | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.abb.2011.10.018 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-NoDerivatives | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | OAPOT | en_US |
dc.title | At the membrane frontier: A prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hartley, Meredith D., and Barbara Imperiali. “At the Membrane Frontier: A Prospectus on the Remarkable Evolutionary Conservation of Polyprenols and Polyprenyl-Phosphates.” Archives of Biochemistry and Biophysics 517, no. 2 (January 2012): 83–97. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Hartley, Meredith D. | en_US |
dc.contributor.mitauthor | Imperiali, Barbara | en_US |
dc.relation.journal | Archives of Biochemistry and Biophysics | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Hartley, Meredith D.; Imperiali, Barbara | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-5749-7869 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |