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dc.contributor.authorHartley, Meredith D.
dc.contributor.authorImperiali, Barbara
dc.date.accessioned2016-02-24T16:58:30Z
dc.date.available2016-02-24T16:58:30Z
dc.date.issued2011-11
dc.date.submitted2011-10
dc.identifier.issn00039861
dc.identifier.issn1096-0384
dc.identifier.urihttp://hdl.handle.net/1721.1/101254
dc.description.abstractLong-chain polyprenols and polyprenyl-phosphates are ubiquitous and essential components of cellular membranes throughout all domains of life. Polyprenyl-phosphates, which include undecaprenyl-phosphate in bacteria and the dolichyl-phosphates in archaea and eukaryotes, serve as specific membrane-bound carriers in glycan biosynthetic pathways responsible for the production of cellular structures such as N-linked protein glycans and bacterial peptidoglycan. Polyprenyl-phosphates are the only form of polyprenols with a biochemically-defined role; however, unmodified or esterified polyprenols often comprise significant percentages of the cellular polyprenol pool. The strong evolutionary conservation of unmodified polyprenols as membrane constituents and polyprenyl-phosphates as preferred glycan carriers in biosynthetic pathways is poorly understood. This review surveys the available research to explore why unmodified polyprenols have been conserved in evolution and why polyprenyl-phosphates are universally and specifically utilized for membrane-bound glycan assembly.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (GM039334)en_US
dc.description.sponsorshipAmerican Chemical Society. Medicinal Chemistry Division (Graduate Fellowship)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.abb.2011.10.018en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceOAPOTen_US
dc.titleAt the membrane frontier: A prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphatesen_US
dc.typeArticleen_US
dc.identifier.citationHartley, Meredith D., and Barbara Imperiali. “At the Membrane Frontier: A Prospectus on the Remarkable Evolutionary Conservation of Polyprenols and Polyprenyl-Phosphates.” Archives of Biochemistry and Biophysics 517, no. 2 (January 2012): 83–97.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorHartley, Meredith D.en_US
dc.contributor.mitauthorImperiali, Barbaraen_US
dc.relation.journalArchives of Biochemistry and Biophysicsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHartley, Meredith D.; Imperiali, Barbaraen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5749-7869
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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