14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
Author(s)Gardino, Alexandra K.; Yaffe, Michael B
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14-3-3 proteins play critical roles in the regulation of cell fate through phospho-dependent binding to a large number of intracellular proteins that are targeted by various classes of protein kinases. 14-3-3 proteins play particularly important roles in coordinating progression of cells through the cell cycle, regulating their response to DNA damage, and influencing life-death decisions following internal injury or external cytokine-mediated cues. This review focuses on 14-3-3-dependent pathways that control cell cycle arrest and recovery, and the influence of 14-3-3 on the apoptotic machinery at multiple levels of regulation. Recognition of 14-3-3 proteins as signaling integrators that connect protein kinase signaling pathways to resulting cellular phenotypes, and their exquisite control through feedforward and feedback loops, identifies new drug targets for human disease, and highlights the emerging importance of using systems-based approaches to understand signal transduction events at the network biology level.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Seminars in Cell & Developmental Biology
Gardino, Alexandra K., and Michael B. Yaffe. “14-3-3 Proteins as Signaling Integration Points for Cell Cycle Control and Apoptosis.” Seminars in Cell & Developmental Biology 22, no. 7 (September 2011): 688–95.
Author's final manuscript