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dc.contributor.authorNizamoglu, Sedat
dc.contributor.authorGather, Malte C.
dc.contributor.authorChoi, Myunghwan
dc.contributor.authorKim, Seonghoon
dc.contributor.authorKim, Ki Su
dc.contributor.authorHahn, Sei Kwang
dc.contributor.authorScarcelli, Giuliano
dc.contributor.authorRandolph, Mark
dc.contributor.authorRedmond, Robert W.
dc.contributor.authorYun, Seok Hyun (Andy)
dc.contributor.authorHumar, Matjaz
dc.date.accessioned2016-03-18T17:08:26Z
dc.date.available2016-03-18T17:08:26Z
dc.date.issued2016-01
dc.date.submitted2015-06
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/101743
dc.description.abstractAdvances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R21EB013761)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (P41EB015903)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01CA192878)en_US
dc.description.sponsorshipUnited States. Dept. of Defense (FA9550-13-1-0068)en_US
dc.description.sponsorshipBullock-Wellman Fellowshipen_US
dc.description.sponsorshipMarie Curie International Fellowship (Career Integration Grant 631679)en_US
dc.description.sponsorshipSeventh Framework Programme (European Commission) (Marie Curie International Outgoing Fellowship Grant 627274)en_US
dc.description.sponsorshipHuman Frontier Science Program (Strasbourg, France) (Young Investigator Grant RGY0074/2013)en_US
dc.description.sponsorshipNational Research Foundation of Korea. Bio & Medical Technology Development Program (2012M3A9C6049791)en_US
dc.description.sponsorshipKorea (South). Ministry of Knowledge Economy (National IT Industry Promotion Agency IITP-2015-R0346-15-1007)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms10374en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNature Publishing Groupen_US
dc.titleBioabsorbable polymer optical waveguides for deep-tissue photomedicineen_US
dc.typeArticleen_US
dc.identifier.citationNizamoglu, Sedat, Malte C. Gather, Matjaž Humar, Myunghwan Choi, Seonghoon Kim, Ki Su Kim, Sei Kwang Hahn, et al. “Bioabsorbable Polymer Optical Waveguides for Deep-Tissue Photomedicine.” Nat Comms 7 (January 19, 2016): 10374.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorYun, Seok Hyun (Andy)en_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsNizamoglu, Sedat; Gather, Malte C.; Humar, Matjaž; Choi, Myunghwan; Kim, Seonghoon; Kim, Ki Su; Hahn, Sei Kwang; Scarcelli, Giuliano; Randolph, Mark; Redmond, Robert W.; Yun, Seok Hyunen_US
mit.licensePUBLISHER_CCen_US


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