dc.contributor.author | Nizamoglu, Sedat | |
dc.contributor.author | Gather, Malte C. | |
dc.contributor.author | Choi, Myunghwan | |
dc.contributor.author | Kim, Seonghoon | |
dc.contributor.author | Kim, Ki Su | |
dc.contributor.author | Hahn, Sei Kwang | |
dc.contributor.author | Scarcelli, Giuliano | |
dc.contributor.author | Randolph, Mark | |
dc.contributor.author | Redmond, Robert W. | |
dc.contributor.author | Yun, Seok Hyun (Andy) | |
dc.contributor.author | Humar, Matjaz | |
dc.date.accessioned | 2016-03-18T17:08:26Z | |
dc.date.available | 2016-03-18T17:08:26Z | |
dc.date.issued | 2016-01 | |
dc.date.submitted | 2015-06 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/101743 | |
dc.description.abstract | Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (R21EB013761) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (P41EB015903) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (R01CA192878) | en_US |
dc.description.sponsorship | United States. Dept. of Defense (FA9550-13-1-0068) | en_US |
dc.description.sponsorship | Bullock-Wellman Fellowship | en_US |
dc.description.sponsorship | Marie Curie International Fellowship (Career Integration Grant 631679) | en_US |
dc.description.sponsorship | Seventh Framework Programme (European Commission) (Marie Curie International Outgoing Fellowship Grant 627274) | en_US |
dc.description.sponsorship | Human Frontier Science Program (Strasbourg, France) (Young Investigator Grant RGY0074/2013) | en_US |
dc.description.sponsorship | National Research Foundation of Korea. Bio & Medical Technology Development Program (2012M3A9C6049791) | en_US |
dc.description.sponsorship | Korea (South). Ministry of Knowledge Economy (National IT Industry Promotion Agency IITP-2015-R0346-15-1007) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/ncomms10374 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Nature Publishing Group | en_US |
dc.title | Bioabsorbable polymer optical waveguides for deep-tissue photomedicine | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Nizamoglu, Sedat, Malte C. Gather, Matjaž Humar, Myunghwan Choi, Seonghoon Kim, Ki Su Kim, Sei Kwang Hahn, et al. “Bioabsorbable Polymer Optical Waveguides for Deep-Tissue Photomedicine.” Nat Comms 7 (January 19, 2016): 10374. | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.mitauthor | Yun, Seok Hyun (Andy) | en_US |
dc.relation.journal | Nature Communications | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Nizamoglu, Sedat; Gather, Malte C.; Humar, Matjaž; Choi, Myunghwan; Kim, Seonghoon; Kim, Ki Su; Hahn, Sei Kwang; Scarcelli, Giuliano; Randolph, Mark; Redmond, Robert W.; Yun, Seok Hyun | en_US |
mit.license | PUBLISHER_CC | en_US |