Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

Author(s)
Aceto, Nicola; Lim, Eugene J.; Sullivan, James P.; Jensen, Anne E.; Zeinali, Mahnaz; ... Show more
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Abstract
A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
Date issued
2015-01
URI
http://hdl.handle.net/1721.1/101769
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Reategui, Eduardo, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne E. Jensen, Mahnaz Zeinali, Joseph M. Martel, et al. “Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells.” Advanced Materials 27, no. 9 (January 15, 2015): 1593–1599.
Version: Author's final manuscript
ISSN
09359648
1521-4095
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