Neurobiology of obsessive–compulsive disorder: insights into neural circuitry dysfunction through mouse genetics
Author(s)Feng, Guoping; Ting, Jonathan Thomas
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The precise causal factors for obsessive–compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive–repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive–repetitive behaviors.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MIT
Current Opinion in Neurobiology
Ting, Jonathan T, and Guoping Feng. “Neurobiology of Obsessive–compulsive Disorder: Insights into Neural Circuitry Dysfunction through Mouse Genetics.” Current Opinion in Neurobiology 21, no. 6 (December 2011): 842–848.
Author's final manuscript