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dc.contributor.authorHolt, Daphne J.
dc.contributor.authorCassidy, Brittany S.
dc.contributor.authorAndrews-Hanna, Jessica R.
dc.contributor.authorLee, Su Mei
dc.contributor.authorCoombs, Garth
dc.contributor.authorGoff, Donald C.
dc.contributor.authorMoran, Joseph M.
dc.contributor.authorGabrieli, John D. E.
dc.date.accessioned2016-04-06T17:17:02Z
dc.date.available2016-04-06T17:17:02Z
dc.date.issued2010-12
dc.date.submitted2010-10
dc.identifier.issn00063223
dc.identifier.urihttp://hdl.handle.net/1721.1/102183
dc.description.abstractBackground Deficits in social cognition, including impairments in self-awareness, contribute to the overall functional disability associated with schizophrenia. Studies in healthy subjects have shown that social cognitive functions, including self-reflection, rely on the medial prefrontal cortex (mPFC) and posterior cingulate gyrus, and these regions exhibit highly correlated activity during “resting” states. In this study, we tested the hypothesis that patients with schizophrenia show dysfunction of this network during self-reflection and that this abnormal activity is associated with changes in the strength of resting-state correlations between these regions. Methods Activation during self-reflection and control tasks was measured with functional magnetic resonance imaging in 19 patients with schizophrenia and 20 demographically matched control subjects. In addition, the resting-state functional connectivity of midline cortical areas showing abnormal self-reflection-related activation in schizophrenia was measured. Results Compared with control subjects, the schizophrenia patients demonstrated lower activation of the right ventral mPFC and greater activation of the mid/posterior cingulate gyri bilaterally during self-reflection, relative to a control task. A similar pattern was seen during overall social reflection. In addition, functional connectivity between the portion of the left mid/posterior cingulate gyrus showing abnormally elevated activity during self-reflection in schizophrenia, and the dorsal anterior cingulate gyrus was lower in the schizophrenia patients compared with control subjects. Conclusions Schizophrenia is associated with an anterior-to-posterior shift in introspection-related activation, as well as changes in functional connectivity, of the midline cortex. These findings provide support for the hypothesis that aberrant midline cortical function contributes to social cognitive impairment in schizophrenia.en_US
dc.description.sponsorshipPoitras Center for Affective Disorders Researchen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.biopsych.2010.10.003en_US
dc.rightsCreative Commons Attribution-Noncommercial-NoDerivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleAn Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflectionen_US
dc.typeArticleen_US
dc.identifier.citationHolt, Daphne J., Brittany S. Cassidy, Jessica R. Andrews-Hanna, Su Mei Lee, Garth Coombs, Donald C. Goff, John D. Gabrieli, and Joseph M. Moran. “An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection.” Biological Psychiatry 69, no. 5 (March 2011): 415–423.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorLee, Su Meien_US
dc.contributor.mitauthorGabrieli, John D. E.en_US
dc.contributor.mitauthorMoran, Joseph M.en_US
dc.relation.journalBiological Psychiatryen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHolt, Daphne J.; Cassidy, Brittany S.; Andrews-Hanna, Jessica R.; Lee, Su Mei; Coombs, Garth; Goff, Donald C.; Gabrieli, John D.; Moran, Joseph M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licensePUBLISHER_CCen_US


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