Analyzing the dynamics of brain circuits with temperature: Design and implementation of a miniature thermoelectric device
Author(s)Aronov, Dmitriy; Fee, Michale S.
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Traditional lesion or inactivation methods are useful for determining if a given brain area is involved in the generation of a behavior, but not for determining if circuit dynamics in that area control the timing of the behavior. In contrast, localized mild cooling or heating of a brain area alters the speed of neuronal and circuit dynamics and can reveal the role of that area in the control of timing. It has been shown that miniaturized solid-state heat pumps based on the Peltier effect can be useful for analyzing brain dynamics in small freely behaving animals (Long and Fee, 2008). Here we present a theoretical analysis of these devices and a procedure for optimizing their design. We describe the construction and implementation of one device for cooling surface brain areas, such as cortex, and another device for cooling deep brain regions. We also present measurements of the magnitude and localization of the brain temperature changes produced by these two devices.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal of Neuroscience Methods
Aronov, Dmitriy, and Michale S. Fee. “Analyzing the Dynamics of Brain Circuits with Temperature: Design and Implementation of a Miniature Thermoelectric Device.” Journal of Neuroscience Methods 197, no. 1 (April 2011): 32–47.
Author's final manuscript