The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Author(s)
Choi, Gloria; Yim, Yeong Shin; Wong, Helen; Kim, Sangdoo; Kim, Hyunju; Kim, Sangwon V.; Hoeffer, Charles A.; Littman, Dan R.; Huh, Jun R.; ... Show more Show less
DownloadChoi_The maternal interleukin.pdf (2.306Mb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled in rodents subjected to maternal immune activation (MIA). The immune cell populations critical in the MIA model have not been identified. Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor–related orphan nuclear receptor gamma t (RORγt)–dependent effector T lymphocytes [for example, T helper 17 (T[subscript H]17) cells] and the effector cytokine interleukin-17a (IL-17a) are required in mothers for MIA-induced behavioral abnormalities in offspring. We find that MIA induces an abnormal cortical phenotype, which is also dependent on maternal IL-17a, in the fetal brain. Our data suggest that therapeutic targeting of T[subscript H]17 cells in susceptible pregnant mothers may reduce the likelihood of bearing children with inflammation-induced ASD-like phenotypes.
Date issued
2016-01Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MITJournal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Choi, G. B., Y. S. Yim, H. Wong, S. Kim, H. Kim, S. V. Kim, C. A. Hoeffer, D. R. Littman, and J. R. Huh. “The Maternal Interleukin-17a Pathway in Mice Promotes Autism-Like Phenotypes in Offspring.” Science 351, no. 6276 (January 28, 2016): 933–939.
Version: Author's final manuscript
ISSN
0036-8075
1095-9203