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dc.contributor.authorZou, James Y.
dc.contributor.authorPark, Danny S.
dc.contributor.authorBurchard, Esteban G.
dc.contributor.authorTorgerson, Dara G.
dc.contributor.authorPino-Yanes, Maria
dc.contributor.authorSong, Yun S.
dc.contributor.authorSankararaman, Sriram
dc.contributor.authorHalperin, Eran
dc.contributor.authorZaitlen, Noah
dc.date.accessioned2016-05-04T14:55:05Z
dc.date.available2016-05-04T14:55:05Z
dc.date.issued2015-11
dc.date.submitted2015-01
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/102394
dc.description.abstractNonrandom mating in human populations has important implications for genetics and medicine as well as for economics and sociology. In this study, we performed an integrative analysis of a large cohort of Mexican and Puerto Rican couples using detailed socioeconomic attributes and genotypes. We found that in ethnically homogeneous Latino communities, partners are significantly more similar in their genomic ancestries than expected by chance. Consistent with this, we also found that partners are more closely related—equivalent to between third and fourth cousins in Mexicans and Puerto Ricans—than matched random male–female pairs. Our analysis showed that this genomic ancestry similarity cannot be explained by the standard socioeconomic measurables alone. Strikingly, the assortment of genomic ancestry in couples was consistently stronger than even the assortment of education. We found enriched correlation of partners’ genotypes at genes known to be involved in facial development. We replicated our results across multiple geographic locations. We discuss the implications of assortment and assortment-specific loci on disease dynamics and disease mapping methods in Latinos.en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1501741112en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceNational Academy of Sciences (U.S.)en_US
dc.titleGenetic and socioeconomic study of mate choice in Latinos reveals novel assortment patternsen_US
dc.typeArticleen_US
dc.identifier.citationZou, James Y., Danny S. Park, Esteban G. Burchard, Dara G. Torgerson, Maria Pino-Yanes, Yun S. Song, Sriram Sankararaman, Eran Halperin, and Noah Zaitlen. “Genetic and Socioeconomic Study of Mate Choice in Latinos Reveals Novel Assortment Patterns.” Proc Natl Acad Sci USA 112, no. 44 (October 19, 2015): 13621–13626.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorZou, James Y.en_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZou, James Y.; Park, Danny S.; Burchard, Esteban G.; Torgerson, Dara G.; Pino-Yanes, Maria; Song, Yun S.; Sankararaman, Sriram; Halperin, Eran; Zaitlen, Noahen_US
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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