dc.contributor.author | Zou, James Y. | |
dc.contributor.author | Park, Danny S. | |
dc.contributor.author | Burchard, Esteban G. | |
dc.contributor.author | Torgerson, Dara G. | |
dc.contributor.author | Pino-Yanes, Maria | |
dc.contributor.author | Song, Yun S. | |
dc.contributor.author | Sankararaman, Sriram | |
dc.contributor.author | Halperin, Eran | |
dc.contributor.author | Zaitlen, Noah | |
dc.date.accessioned | 2016-05-04T14:55:05Z | |
dc.date.available | 2016-05-04T14:55:05Z | |
dc.date.issued | 2015-11 | |
dc.date.submitted | 2015-01 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/102394 | |
dc.description.abstract | Nonrandom mating in human populations has important implications for genetics and medicine as well as for economics and sociology. In this study, we performed an integrative analysis of a large cohort of Mexican and Puerto Rican couples using detailed socioeconomic attributes and genotypes. We found that in ethnically homogeneous Latino communities, partners are significantly more similar in their genomic ancestries than expected by chance. Consistent with this, we also found that partners are more closely related—equivalent to between third and fourth cousins in Mexicans and Puerto Ricans—than matched random male–female pairs. Our analysis showed that this genomic ancestry similarity cannot be explained by the standard socioeconomic measurables alone. Strikingly, the assortment of genomic ancestry in couples was consistently stronger than even the assortment of education. We found enriched correlation of partners’ genotypes at genes known to be involved in facial development. We replicated our results across multiple geographic locations. We discuss the implications of assortment and assortment-specific loci on disease dynamics and disease mapping methods in Latinos. | en_US |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences (U.S.) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1501741112 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | National Academy of Sciences (U.S.) | en_US |
dc.title | Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Zou, James Y., Danny S. Park, Esteban G. Burchard, Dara G. Torgerson, Maria Pino-Yanes, Yun S. Song, Sriram Sankararaman, Eran Halperin, and Noah Zaitlen. “Genetic and Socioeconomic Study of Mate Choice in Latinos Reveals Novel Assortment Patterns.” Proc Natl Acad Sci USA 112, no. 44 (October 19, 2015): 13621–13626. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.mitauthor | Zou, James Y. | en_US |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Zou, James Y.; Park, Danny S.; Burchard, Esteban G.; Torgerson, Dara G.; Pino-Yanes, Maria; Song, Yun S.; Sankararaman, Sriram; Halperin, Eran; Zaitlen, Noah | en_US |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |