Lesions of prefrontal cortex reduce attentional modulation of neuronal responses and synchrony in V4
Author(s)
Desimone, Robert; Gregoriou, Georgia G.; Rossi, Andrew F.; Ungerleider, Leslie G.
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It is widely held that the frontal eye field (FEF) in prefrontal cortex (PFC) modulates processing in visual cortex with attention, although the evidence that it is necessary is equivocal. To help identify critical sources of attentional feedback to area V4, we surgically removed the entire lateral PFC, including the FEF, in one hemisphere and transected the corpus callosum and anterior commissure in two macaques. This deprived V4 of PFC input in one hemisphere while keeping the other hemisphere intact. In the absence of PFC, attentional effects on neuronal responses and synchrony in V4 were substantially reduced and the remaining effects of attention were delayed in time, indicating a critical role for PFC. Conversely, distracters captured attention and influenced V4 responses. However, because the effects of attention in V4 were not eliminated by PFC lesions, other sources of top-down attentional control signals to visual cortex must exist outside of PFC.
Date issued
2014-06Department
McGovern Institute for Brain Research at MITJournal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Gregoriou, Georgia G, Andrew F Rossi, Leslie G Ungerleider, and Robert Desimone. “Lesions of Prefrontal Cortex Reduce Attentional Modulation of Neuronal Responses and Synchrony in V4.” Nat Neurosci 17, no. 7 (June 15, 2014): 1003–1011.
Version: Author's final manuscript
ISSN
1097-6256
1546-1726