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Basal ganglia output to the thalamus: still a paradox

Author(s)
Goldberg, Jesse H.; Farries, Michael A.; Fee, Michale S.
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Abstract
The basal ganglia (BG)-recipient thalamus controls motor output but it remains unclear how its activity is regulated. Several studies report that thalamic activation occurs via disinhibition during pauses in the firing of inhibitory pallidal inputs from the BG. Other studies indicate that thalamic spiking is triggered by pallidal inputs via post-inhibitory ‘rebound’ calcium spikes. Finally excitatory cortical inputs can drive thalamic activity, which becomes entrained, or time-locked, to pallidal spikes. We present a unifying framework where these seemingly distinct results arise from a continuum of thalamic firing ‘modes’ controlled by excitatory inputs. We provide a mechanistic explanation for paradoxical pallidothalamic coactivations observed during behavior that raises new questions about what information is integrated in the thalamus to control behavior.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/102409
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; McGovern Institute for Brain Research at MIT
Journal
Trends in Neurosciences
Publisher
Elsevier
Citation
Goldberg, Jesse H., Michael A. Farries, and Michale S. Fee. “Basal Ganglia Output to the Thalamus: Still a Paradox.” Trends in Neurosciences 36, no. 12 (December 2013): 695–705.
Version: Author's final manuscript
ISSN
01662236

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