dc.contributor.author | Namburi, Praneeth | |
dc.contributor.author | Beyeler, Anna | |
dc.contributor.author | Yorozu, Suzuko | |
dc.contributor.author | Calhoon, Gwendolyn G. | |
dc.contributor.author | Wichmann, Romy | |
dc.contributor.author | Holden, Stephanie S. | |
dc.contributor.author | Mertens, Kim L. | |
dc.contributor.author | Wickersham, Ian R. | |
dc.contributor.author | Gray, Jesse M. | |
dc.contributor.author | Halbert, Sarah | |
dc.contributor.author | Anahtar, Melodi N. | |
dc.contributor.author | Felix-Ortiz, Ada Celis | |
dc.contributor.author | Tye, Kay | |
dc.date.accessioned | 2016-05-18T13:58:05Z | |
dc.date.available | 2016-05-18T13:58:05Z | |
dc.date.issued | 2015-04 | |
dc.date.submitted | 2014-04 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.issn | 1476-4687 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/102520 | |
dc.description.abstract | The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and negative. Different populations of BLA neurons may encode fearful or rewarding associations, but the identifying features of these populations and the synaptic mechanisms of differentiating positive and negative emotional valence have remained unknown. Here we show that BLA neurons projecting to the nucleus accumbens (NAc projectors) or the centromedial amygdala (CeM projectors) undergo opposing synaptic changes following fear or reward conditioning. We find that photostimulation of NAc projectors supports positive reinforcement while photostimulation of CeM projectors mediates negative reinforcement. Photoinhibition of CeM projectors impairs fear conditioning and enhances reward conditioning. We characterize these functionally distinct neuronal populations by comparing their electrophysiological, morphological and genetic features. Overall, we provide a mechanistic explanation for the representation of positive and negative associations within the amygdala. | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (R01-MH102441-01) | en_US |
dc.description.sponsorship | National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (DP2-DK-102256-01) | en_US |
dc.description.sponsorship | JPB Foundation | en_US |
dc.description.sponsorship | Brain & Behavior Research Foundation | en_US |
dc.description.sponsorship | Klingenstein Foundation | en_US |
dc.description.sponsorship | Whitehall Foundation | en_US |
dc.description.sponsorship | Alfred P. Sloan Foundation | en_US |
dc.description.sponsorship | Singleton Fellowship | en_US |
dc.description.sponsorship | MIT Presidential Marcus Fellowship to Honor Norman B. Leventhal | en_US |
dc.description.sponsorship | Whitaker Foundation (Fellowship) | en_US |
dc.description.sponsorship | Swiss National Science Foundation (Fellowship) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Simons Center for the Social Brain (Postdoctoral Fellowship) | en_US |
dc.description.sponsorship | NWO of the Netherlands (Rubicon Award) | en_US |
dc.description.sponsorship | McGovern Institute for Brain Research at MIT (Seed Grant) | en_US |
dc.description.sponsorship | Picower Institute for Learning and Memory (Seed Grant) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Seed Grant) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Simons Center for the Social Brain (Seed Grant) | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (BRAIN Initiative Award) | en_US |
dc.description.sponsorship | National Eye Institute (BRAIN Initiative Award) | en_US |
dc.description.sponsorship | National Institute of Neurological Disorders and Stroke (U.S.) (BRAIN Initiative Award U01-MH106018) | en_US |
dc.description.sponsorship | National Institute of Neurological Disorders and Stroke (U.S.) (BRAIN Initiative Award U01-NS090473) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (IOS-1451202) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/nature14366 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | A circuit mechanism for differentiating positive and negative associations | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Namburi, Praneeth, Anna Beyeler, Suzuko Yorozu, Gwendolyn G. Calhoon, Sarah A. Halbert, Romy Wichmann, Stephanie S. Holden, et al. “A Circuit Mechanism for Differentiating Positive and Negative Associations.” Nature 520, no. 7549 (April 30, 2015): 675–78. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.department | Picower Institute for Learning and Memory | en_US |
dc.contributor.mitauthor | Namburi, Praneeth | en_US |
dc.contributor.mitauthor | Beyeler, Anna | en_US |
dc.contributor.mitauthor | Calhoon, Gwendolyn G. | en_US |
dc.contributor.mitauthor | Halbert, Sarah | en_US |
dc.contributor.mitauthor | Wichmann, Romy | en_US |
dc.contributor.mitauthor | Holden, Stephanie S. | en_US |
dc.contributor.mitauthor | Mertens, Kim L. | en_US |
dc.contributor.mitauthor | Anahtar, Melodi N. | en_US |
dc.contributor.mitauthor | Felix-Ortiz, Ada Celis | en_US |
dc.contributor.mitauthor | Wickersham, Ian R. | en_US |
dc.contributor.mitauthor | Tye, Kay | en_US |
dc.relation.journal | Nature | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Namburi, Praneeth; Beyeler, Anna; Yorozu, Suzuko; Calhoon, Gwendolyn G.; Halbert, Sarah A.; Wichmann, Romy; Holden, Stephanie S.; Mertens, Kim L.; Anahtar, Melodi; Felix-Ortiz, Ada C.; Wickersham, Ian R.; Gray, Jesse M.; Tye, Kay M. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-2371-5706 | |
dc.identifier.orcid | https://orcid.org/0000-0002-1410-8675 | |
dc.identifier.orcid | https://orcid.org/0000-0003-0652-5652 | |
dc.identifier.orcid | https://orcid.org/0000-0002-4191-6926 | |
dc.identifier.orcid | https://orcid.org/0000-0002-4506-8813 | |
mit.license | PUBLISHER_POLICY | en_US |