dc.contributor.author | Shitreet, Sagi | |
dc.contributor.author | Abraham, Eytan | |
dc.contributor.author | Stanley, Butch | |
dc.contributor.author | Artzi, Natalie | |
dc.contributor.author | Edelman, Elazer R | |
dc.contributor.author | Oliva, Nuria | |
dc.date.accessioned | 2016-05-22T18:52:50Z | |
dc.date.available | 2016-05-22T18:52:50Z | |
dc.date.issued | 2012-10 | |
dc.date.submitted | 2012-09 | |
dc.identifier.issn | 0743-7463 | |
dc.identifier.issn | 1520-5827 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/102571 | |
dc.description.abstract | We designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive interface created by a dextran aldehyde-selective reaction with tissue amines. By altering aldehyde–amine chemistry, we examined how variations in tissue surfaces (serosal amine density in the duodenum, jejunum, and ileum) affect interactions with adhesive materials of varied compositions (aldehyde content). Interestingly, the same adhesive formulation reacts differentially with the three regions of the small intestine as a result of variation in the tissue amine density along the intestinal tract, affecting the tissue–material interfacial morphology, adhesion strength, and adhesive mechanical properties. Whereas tissues provide chemical anchors for interaction with materials, we were able to tune the adhesion strength for each section of the small intestine tissue by altering the adhesive formulation using a two-component material with flexible variables aimed at controlling the aldehyde/amine ratio. This tissue-specific approach should be applied to the broad spectrum of biomaterials, taking into account specific microenvironmental conditions in material design. | en_US |
dc.description.sponsorship | Deshpande Center for Technological Innovation | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant RO1 GM 49039) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/la303155p | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Oliva, Nuria, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. “Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance.” Langmuir 28, no. 43 (October 30, 2012): 15402–15409. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.mitauthor | Oliva Jorge, Nuria | en_US |
dc.contributor.mitauthor | Shitreet, Sagi | en_US |
dc.contributor.mitauthor | Abraham, Eytan | en_US |
dc.contributor.mitauthor | Edelman, Elazer R. | en_US |
dc.contributor.mitauthor | Artzi, Natalie | en_US |
dc.relation.journal | Langmuir | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Oliva, Nuria; Shitreet, Sagi; Abraham, Eytan; Stanley, Butch; Edelman, Elazer R.; Artzi, Natalie | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3055-797X | |
dc.identifier.orcid | https://orcid.org/0000-0002-7832-7156 | |
mit.license | PUBLISHER_POLICY | en_US |