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dc.contributor.authorShitreet, Sagi
dc.contributor.authorAbraham, Eytan
dc.contributor.authorStanley, Butch
dc.contributor.authorArtzi, Natalie
dc.contributor.authorEdelman, Elazer R
dc.contributor.authorOliva, Nuria
dc.date.accessioned2016-05-22T18:52:50Z
dc.date.available2016-05-22T18:52:50Z
dc.date.issued2012-10
dc.date.submitted2012-09
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.urihttp://hdl.handle.net/1721.1/102571
dc.description.abstractWe designed and optimized tissue-responsive adhesive materials by matching material and tissue properties. A two-component material based on dextran aldehyde and dendrimer amine provides a cohesive gel through aldehyde–amine cross-linking and an adhesive interface created by a dextran aldehyde-selective reaction with tissue amines. By altering aldehyde–amine chemistry, we examined how variations in tissue surfaces (serosal amine density in the duodenum, jejunum, and ileum) affect interactions with adhesive materials of varied compositions (aldehyde content). Interestingly, the same adhesive formulation reacts differentially with the three regions of the small intestine as a result of variation in the tissue amine density along the intestinal tract, affecting the tissue–material interfacial morphology, adhesion strength, and adhesive mechanical properties. Whereas tissues provide chemical anchors for interaction with materials, we were able to tune the adhesion strength for each section of the small intestine tissue by altering the adhesive formulation using a two-component material with flexible variables aimed at controlling the aldehyde/amine ratio. This tissue-specific approach should be applied to the broad spectrum of biomaterials, taking into account specific microenvironmental conditions in material design.en_US
dc.description.sponsorshipDeshpande Center for Technological Innovationen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RO1 GM 49039)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/la303155pen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleNatural Tissue Microenvironmental Conditions Modulate Adhesive Material Performanceen_US
dc.typeArticleen_US
dc.identifier.citationOliva, Nuria, Sagi Shitreet, Eytan Abraham, Butch Stanley, Elazer R. Edelman, and Natalie Artzi. “Natural Tissue Microenvironmental Conditions Modulate Adhesive Material Performance.” Langmuir 28, no. 43 (October 30, 2012): 15402–15409.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorOliva Jorge, Nuriaen_US
dc.contributor.mitauthorShitreet, Sagien_US
dc.contributor.mitauthorAbraham, Eytanen_US
dc.contributor.mitauthorEdelman, Elazer R.en_US
dc.contributor.mitauthorArtzi, Natalieen_US
dc.relation.journalLangmuiren_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsOliva, Nuria; Shitreet, Sagi; Abraham, Eytan; Stanley, Butch; Edelman, Elazer R.; Artzi, Natalieen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3055-797X
dc.identifier.orcidhttps://orcid.org/0000-0002-7832-7156
mit.licensePUBLISHER_POLICYen_US


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