Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity
Author(s)Thomazeau, Aurore; Kaplan, Eitan S.; Cooke, Samuel Frazer; Komorowski, Robert; Chubykin, Alexander A.; Khibnik, Lena A.; Gavornik, Jeffrey P.; Bear, Mark; ... Show more Show less
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The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
eLife Sciences Publications, Ltd.
Kaplan, Eitan S, Sam F Cooke, Robert W Komorowski, Alexander A Chubykin, Aurore Thomazeau, Lena A Khibnik, Jeffrey P Gavornik, and Mark F Bear. “Contrasting Roles for Parvalbumin-Expressing Inhibitory Neurons in Two Forms of Adult Visual Cortical Plasticity.” eLife 5 (March 4, 2016).
Final published version