Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation
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Tye_Dorsal raphe.pdf
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5.64 MB
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Author(s)
Matthews, Gillian A.
Nieh, Edward H.
Vander Weele, Caitlin M.
Halbert, Sarah A.
Pradhan, Roma V.
Yosafat, Ariella S.
Glober, Gordon F.
Izadmehr, Ehsan M.
Thomas, Rain E.
Lacy, Gabrielle D.
Date Issued
February 2016
Journal
Cell
Publisher
Cell Press/Elsevier
Citation
Matthews, Gillian A., Edward H. Nieh, Caitlin M. Vander Weele, Sarah A. Halbert, Roma V. Pradhan, Ariella S. Yosafat, Gordon F. Glober, et al. “Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation.” Cell 164, no. 4 (February 2016): 617–631.
Version
Final published version
Abstract
The motivation to seek social contact may arise from either positive or negative emotional states, as social interaction can be rewarding and social isolation can be aversive. While ventral tegmental area (VTA) dopamine (DA) neurons may mediate social reward, a cellular substrate for the negative affective state of loneliness has remained elusive. Here, we identify a functional role for DA neurons in the dorsal raphe nucleus (DRN), in which we observe synaptic changes following acute social isolation. DRN DA neurons
show increased activity upon social contact following isolation, revealed by in vivo calcium imaging. Optogenetic activation of DRN DA neurons increases social preference but causes place avoidance. Furthermore, these neurons are necessary for promoting rebound sociability following an acute period of isolation. Finally, the degree to which these neurons modulate behavior is predicted by social rank, together supporting a role for DRN dopamine neurons in mediating a loneliness-like state.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2015.12.040
