miRNAs in atherosclerotic plaque initiation, progression, and rupture
Author(s)Andreou, Ioannis; Sun, Xinghui; Stone, Peter H.; Edelman, Elazer R.; Feinberg, Mark W.
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Atherosclerosis is a chronic immune-inflammatory disorder that integrates multiple cell types and a diverse set of inflammatory mediators. miRNAs are emerging as important post-transcriptional regulators of gene expression in most, if not all, vertebrate cells, and constitute central players in many physiological and pathological processes. Rapidly accumulating experimental studies reveal their key role in cellular and molecular processes related to the development of atherosclerosis. We review current evidence for the involvement of miRNAs in early atherosclerotic lesion formation and in plaque rupture and erosion. We conclude with a perspective on the clinical relevance, therapeutic opportunities, and future challenges of miRNA biology in understanding the pathogenesis of this complex disease.
DepartmentInstitute for Medical Engineering and Science
Trends in Molecular Medicine
Andreou, Ioannis, Xinghui Sun, Peter H. Stone, Elazer R. Edelman, and Mark W. Feinberg. “miRNAs in Atherosclerotic Plaque Initiation, Progression, and Rupture.” Trends in Molecular Medicine 21, no. 5 (May 2015): 307–318.
Author's final manuscript