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Ligands influence a carbon nanotube penetration through a lipid bilayer

Author(s)
Liu, Fei; Wu, Dan; Chen, Ken
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
The interactions between nanomaterials and biological membranes are important for the safe use of nanomaterials. We explore the nano–bio interface by studying the penetration of a carbon nanotube (CNT) coated with ligands through a lipid bilayer. With a dissipative particle dynamics model, the mechanism of ligands influencing nano–bio interaction is analyzed. The CNTs with different ligands are tested. The simulation shows that the increase of the total number of ligand particles decreases the capability of a CNT penetrating through a membrane. For the CNTs with the same number of ligand particles, the arrangements of their ligands determine their behaviors. The asymmetrical pattern generates an upside down phenomenon, which requires more energy to get through the membrane; the uniform distribution penetrates through a membrane with less difficulty. Decreasing the stiffness, the length of ligands or preferring hydrophobic ligands increases the penetration capability of CNTs.
Date issued
2014-10
URI
http://hdl.handle.net/1721.1/103365
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Journal of Nanoparticle Research
Publisher
Springer Netherlands
Citation
Liu, Fei, Dan Wu, and Ken Chen. "Ligands influence a carbon nanotube penetration through a lipid bilayer." Journal of Nanoparticle Research November 2014, 16:2692.
Version: Author's final manuscript
ISSN
1388-0764
1572-896X

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