| dc.contributor.author | Prevedel, Robert | |
| dc.contributor.author | Yoon, Young-Gyu | |
| dc.contributor.author | Hoffmann, Maximilian | |
| dc.contributor.author | Pak, Nikita | |
| dc.contributor.author | Wetzstein, Gordon | |
| dc.contributor.author | Kato, Saul | |
| dc.contributor.author | Schrödel, Tina | |
| dc.contributor.author | Raskar, Ramesh | |
| dc.contributor.author | Zimmer, Manuel | |
| dc.contributor.author | Boyden, Edward Stuart | |
| dc.contributor.author | Vaziri, Alipasha | |
| dc.date.accessioned | 2016-07-08T16:56:10Z | |
| dc.date.available | 2016-07-08T16:56:10Z | |
| dc.date.issued | 2014-05 | |
| dc.date.submitted | 2014-01 | |
| dc.identifier.issn | 1548-7091 | |
| dc.identifier.issn | 1548-7105 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/103551 | |
| dc.description.abstract | High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge in neuroscience. Here we demonstrate simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain. Our technique captures the dynamics of spiking neurons in volumes of ~700 μm × 700 μm × 200 μm at 20 Hz. Its simplicity makes it an attractive tool for high-speed volumetric calcium imaging. | en_US |
| dc.description.sponsorship | European Commission (Marie Curie, FP7-PEOPLE-2011-IIF) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant 1R01EY023173) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (NSF CBET 1053233) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (NSF CBET 1344219) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH 1DP1NS087724) | en_US |
| dc.description.sponsorship | Vienna Science and Technology Fund ((WWTF) project VRG10-11) | en_US |
| dc.description.sponsorship | Seventh Framework Programme (European Commission) (ERC no. 281869) | en_US |
| dc.description.sponsorship | MIT Media Lab Consortium | en_US |
| dc.description.sponsorship | Institution of Engineering and Technology (IET) (Harvey Prize) | en_US |
| dc.description.sponsorship | Human Frontier Science Program (Strasbourg, France) (Project RGP0041/2012) | |
| dc.language.iso | en_US | |
| dc.publisher | Springer Nature | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/nmeth.2964 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Prevedel, Robert, Young-Gyu Yoon, Maximilian Hoffmann, Nikita Pak, Gordon Wetzstein, Saul Kato, Tina Schrödel, Ramesh Raskar, Manuel Zimmer, Edward S. Boyden, and Alipasha Vaziri. “Simultaneous Whole-Animal 3D Imaging of Neuronal Activity Using Light-Field Microscopy.” Nature Methods 11, no. 7 (May 18, 2014): 727–730. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Media Laboratory | en_US |
| dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
| dc.contributor.mitauthor | Yoon, Young-Gyu | en_US |
| dc.contributor.mitauthor | Pak, Nikita | en_US |
| dc.contributor.mitauthor | Wetzstein, Gordon | en_US |
| dc.contributor.mitauthor | Raskar, Ramesh | en_US |
| dc.contributor.mitauthor | Boyden, Edward Stuart | en_US |
| dc.relation.journal | Nature Methods | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Prevedel, Robert; Yoon, Young-Gyu; Hoffmann, Maximilian; Pak, Nikita; Wetzstein, Gordon; Kato, Saul; Schrödel, Tina; Raskar, Ramesh; Zimmer, Manuel; Boyden, Edward S; Vaziri, Alipasha | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-1812-6421 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-2079-0543 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-0419-3351 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-3254-3224 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
