| dc.contributor.author | Su, Erzheng | |
| dc.contributor.author | Klibanov, Alexander M. | |
| dc.date.accessioned | 2016-07-15T22:11:23Z | |
| dc.date.available | 2016-07-15T22:11:23Z | |
| dc.date.issued | 2015-08 | |
| dc.date.submitted | 2015-05 | |
| dc.identifier.issn | 0273-2289 | |
| dc.identifier.issn | 1559-0291 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/103634 | |
| dc.description.abstract | Several diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extreme pHs. Separately, the water-sensitive drug aspirin is found to form concentrated transparent LTTMs, where it is some 10-fold more stable against cleavage than in water. | en_US |
| dc.publisher | Springer US | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1007/s12010-015-1777-x | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | Springer US | en_US |
| dc.title | Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Su, Erzheng, and Alexander M. Klibanov. “Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation.” Applied Biochemistry and Biotechnology 177, no. 3 (August 4, 2015): 753–758. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Klibanov, Alexander M. | en_US |
| dc.contributor.mitauthor | Su, Erzheng | en_US |
| dc.relation.journal | Applied Biochemistry and Biotechnology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2016-05-23T12:17:44Z | |
| dc.language.rfc3066 | en | |
| dc.rights.holder | Springer Science+Business Media New York | |
| dspace.orderedauthors | Su, Erzheng; Klibanov, Alexander M. | en_US |
| dspace.embargo.terms | N | en |
| dc.identifier.orcid | https://orcid.org/0000-0003-3830-714X | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
