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dc.contributor.authorSu, Erzheng
dc.contributor.authorKlibanov, Alexander M.
dc.date.accessioned2016-07-15T22:11:23Z
dc.date.available2016-07-15T22:11:23Z
dc.date.issued2015-08
dc.date.submitted2015-05
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.urihttp://hdl.handle.net/1721.1/103634
dc.description.abstractSeveral diverse proteins are found to readily dissolve in neat low-transition-temperature mixtures (LTTMs). They undergo no irreversible denaturation in such unusual solvents, and the resistance of hen egg-white lysozyme against thermoinactivation in LTTMs is greater than in aqueous solution at extreme pHs. Separately, the water-sensitive drug aspirin is found to form concentrated transparent LTTMs, where it is some 10-fold more stable against cleavage than in water.en_US
dc.publisherSpringer USen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s12010-015-1777-xen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceSpringer USen_US
dc.titleLow-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulationen_US
dc.typeArticleen_US
dc.identifier.citationSu, Erzheng, and Alexander M. Klibanov. “Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation.” Applied Biochemistry and Biotechnology 177, no. 3 (August 4, 2015): 753–758.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorKlibanov, Alexander M.en_US
dc.contributor.mitauthorSu, Erzhengen_US
dc.relation.journalApplied Biochemistry and Biotechnologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2016-05-23T12:17:44Z
dc.language.rfc3066en
dc.rights.holderSpringer Science+Business Media New York
dspace.orderedauthorsSu, Erzheng; Klibanov, Alexander M.en_US
dspace.embargo.termsNen
dc.identifier.orcidhttps://orcid.org/0000-0003-3830-714X
mit.licenseOPEN_ACCESS_POLICYen_US


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