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Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery

dc.contributor.authorBernstein, Jacob G.
dc.contributor.authorAllen, Brian Douglas
dc.contributor.authorGuerra, Alexander A.
dc.contributor.authorBoyden, Edward Stuart
dc.date.accessioned2016-07-18T16:45:01Z
dc.date.available2016-07-18T16:45:01Z
dc.date.issued2015-05
dc.date.submitted2014-11
dc.identifier.issn2051-3305
dc.identifier.urihttp://hdl.handle.net/1721.1/103643
dc.description.abstractOptogenetics enables light to be used to control the activity of genetically targeted cells in the living brain. Optical fibres can be used to deliver light to deep targets, and light-emitting diodes (LEDs) can be spatially arranged to enable patterned light delivery. In combination, arrays of LED-coupled optical fibres can enable patterned light delivery to deep targets in the brain. Here the authors describe the process flow for making LED arrays and LED-coupled optical fibre arrays, explaining key optical, electrical, thermal and mechanical design principles to enable the manufacturing, assembly and testing of such multi-site targetable optical devices. They also explore accessory strategies such as surgical automation approaches as well as innovations to enable low-noise concurrent electrophysiology.en_US
dc.description.sponsorshipMassachusetts Institute of Technology (Hugh Hampton Young Fellowship)en_US
dc.description.sponsorshipInstitution of Engineering and Technology (IET) (Harvey Prize)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Director's New Innovator Award DP2OD002002)en_US
dc.description.sponsorshipWallace H. Coulter Foundationen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant 1RC1MH088182)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant 1RC2DE020919)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant 1R01NS067199)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant 1R43NS070453)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF Grant 0835878)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF Grant 0848804)en_US
dc.description.sponsorshipMcGovern Institute Neurotechnology (MINT) programen_US
dc.description.sponsorshipUnited States. Dept. of Defense (CDMRP PTSD Program)en_US
dc.description.sponsorshipHuman Frontier Science Program (Strasbourg, France)en_US
dc.description.sponsorshipAlfred P. Sloan Foundationen_US
dc.description.sponsorshipBrain & Behavior Research Foundation (NARSAD Young Investigator Award)en_US
dc.language.isoen_US
dc.publisherInstitution of Engineering and Technology (IET)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1049/joe.2014.0304en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.sourceJournal of Engineeringen_US
dc.titleProcesses for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light deliveryen_US
dc.typeArticleen_US
dc.identifier.citationBernstein, Jacob Gold, Brian Douglas Allen, Alexander A. Guerra, and Edward Stuart Boyden. "Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery." Journal of Engineering, 2015, 8 pp.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorBernstein, Jacob G.en_US
dc.contributor.mitauthorAllen, Brian Douglasen_US
dc.contributor.mitauthorGuerra, Alexander A.en_US
dc.contributor.mitauthorBoyden, Edward Stuarten_US
dc.relation.journalJournal of Engineeringen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBoyden, Edward Stuart; Guerra, Alexander A.; Allen, Brian Douglas; Bernstein, Jacob Golden_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9969-4281
dc.identifier.orcidhttps://orcid.org/0000-0002-0419-3351
dc.identifier.orcidhttps://orcid.org/0000-0002-8381-7555
mit.licensePUBLISHER_CCen_US


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