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dc.contributor.authorFukunaga, Izumi
dc.contributor.authorHerb, Jan T.
dc.contributor.authorKollo, Mihaly
dc.contributor.authorBoyden, Edward Stuart
dc.contributor.authorSchaefer, Andreas T.
dc.date.accessioned2016-07-19T14:40:13Z
dc.date.available2016-07-19T14:40:13Z
dc.date.issued2014-07
dc.date.submitted2014-02
dc.identifier.issn1097-6256
dc.identifier.issn1546-1726
dc.identifier.urihttp://hdl.handle.net/1721.1/103754
dc.description.abstractCircuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating baseline and odor-evoked inhibition, whereas granule cells orchestrated gamma synchrony and spike timing. Notably, granule cells did not contribute to baseline rhythms or sniff-coupled odor-evoked inhibition. Thus, activities on theta and gamma timescales are controlled by separate, dissociable inhibitory networks in the olfactory bulb.en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG-SPP1392)en_US
dc.description.sponsorshipMax Planck Society for the Advancement of Scienceen_US
dc.description.sponsorshipAlexander von Humboldt-Stiftungen_US
dc.description.sponsorshipGermany. Federal Ministry of Education and Research (US-German collaboration computational neuroscience)en_US
dc.description.sponsorshipMedical Research Council (Great Britain) (MC_UP_1202/5)en_US
dc.description.sponsorshipUniversity of Tubingen (ExcellenzCluster Cell Networks)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nn.3760en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleIndependent control of gamma and theta activity by distinct interneuron networks in the olfactory bulben_US
dc.typeArticleen_US
dc.identifier.citationFukunaga, Izumi, Jan T Herb, Mihaly Kollo, Edward S Boyden, and Andreas T Schaefer. “Independent Control of Gamma and Theta Activity by Distinct Interneuron Networks in the Olfactory Bulb.” Nat Neurosci 17, no. 9 (July 6, 2014): 1208–1216.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Synthetic Neurobiology Groupen_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.mitauthorBoyden, Edward Stuarten_US
dc.relation.journalNature Neuroscienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFukunaga, Izumi; Herb, Jan T; Kollo, Mihaly; Boyden, Edward S; Schaefer, Andreas Ten_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0419-3351
mit.licenseOPEN_ACCESS_POLICYen_US


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