7.88J / 7.24J / 5.48J / 10.543J Protein Folding Problem, Fall 2007

Author(s)
King, Jonathan
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Alternative title
Protein Folding Problem
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Abstract
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.
Date issued
2007-12
URI
http://hdl.handle.net/1721.1/103817
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry
Other identifiers
7.88J-Fall2007
local: 7.88J
local: 7.24J
local: 5.48J
local: 10.543J
local: IMSCP-MD5-b1f4093c16343d4a95bdb9c82a98d028
Keywords
260404, Developmental Biology and Embryology
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