Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Author(s)Olenchock, Benjamin; Vander Heiden, Matthew G.
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Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Olenchock, Benjamin A., and Matthew G. Vander Heiden. “Pyruvate as a Pivot Point for Oncogene-Induced Senescence.” Cell 153, no. 7 (June 2013): 1429–1430.
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