dc.contributor.author | Yang, Yang | |
dc.contributor.author | Shi, Shi-Liang | |
dc.contributor.author | Niu, Dawen | |
dc.contributor.author | Liu, Peng | |
dc.contributor.author | Buchwald, Stephen Leffler | |
dc.date.accessioned | 2016-08-11T20:09:13Z | |
dc.date.available | 2016-08-11T20:09:13Z | |
dc.date.issued | 2015-07 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/103906 | |
dc.description | Available in PMC 2016 July 03. | en_US |
dc.description.abstract | Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins-an important yet unexploited class of abundant feedstock chemicals-into highly enantioenriched α-branched amines (≥96% enantiomeric excess) featuring two minimally differentiated aliphatic substituents. This method provides a powerful means to access a broad range of advanced, highly functionalized enantioenriched amines of interest in pharmaceutical research and other areas. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM58160) | en_US |
dc.description.sponsorship | University of Pittsburgh | en_US |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1126/science.aab3753 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Yang, Y., S.-L. Shi, D. Niu, P. Liu, and S. L. Buchwald. “Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines.” Science 349, no. 6243 (July 2, 2015): 62–66. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Yang, Yang | en_US |
dc.contributor.mitauthor | Shi, Shi-Liang | en_US |
dc.contributor.mitauthor | Niu, Dawen | en_US |
dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
dc.relation.journal | Science | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Yang, Y.; Shi, S.-L.; Niu, D.; Liu, P.; Buchwald, S. L. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-7917-7620 | |
dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |