Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities
Author(s)Dai, Chunhui; Snead, David; Zhang, Ping; Jamison, Timothy F.
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Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes. Here, we report a total synthesis of atropine in flow that features an unusual hydroxymethylation and separation of several byproducts with high structural similarity to atropine. Using a combination of careful pH control in three sequential liquid-liquid extractions and a functionalized resin, atropine is delivered by the flow system with >98% purity.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of Flow Chemistry
Akadémiai Kiadó Zrt.
Dai, Chunhui, David R. Snead, Ping Zhang, and Timothy F. Jamison. “Continuous-Flow Synthesis and Purification of Atropine with Sequential in-Line Separations of Structurally Similar Impurities.” Journal of Flow Chemistry 5, no. 3 (September 2015): 133–138.
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