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dc.contributor.authorGraf, Nora
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2016-08-16T18:36:09Z
dc.date.available2016-08-16T18:36:09Z
dc.date.issued2012-01
dc.date.submitted2011-06
dc.identifier.issn0169409X
dc.identifier.urihttp://hdl.handle.net/1721.1/103939
dc.description.abstractThis review provides an overview of metal-based anticancer drugs and drug candidates. In particular, we focus on metal complexes that can be activated in the reducing environment of cancer cells, thus serving as prodrugs. There are many reports of Pt and Ru complexes as redox-activatable drug candidates, but other d-block elements with variable oxidation states have a similar potential to serve as prodrugs in this manner. In this context are compounds based on Fe, Co, or Cu chemistry, which are also covered. A trend in the field of medicinal inorganic chemistry has been toward molecularly targeted, metal-based drugs obtained by functionalizing complexes with biologically active ligands. Another recent activity is the use of nanomaterials for drug delivery, exploiting passive targeting of tumors with nano-sized constructs made from Au, Fe, carbon, or organic polymers. Although complexes of all of the above mentioned metals will be described, this review focuses primarily on Pt compounds, including constructs containing nanomaterials.en_US
dc.description.sponsorshipGerman Academic Exchange Service (DAAD fellowship)en_US
dc.description.sponsorshipGerman Academic Exchange Service (DAAD reintegration grant)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (grant CA034992)en_US
dc.language.isoen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.addr.2012.01.007en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceProf. Lippard via Erja Kajosaloen_US
dc.titleRedox activation of metal-based prodrugs as a strategy for drug deliveryen_US
dc.typeArticleen_US
dc.identifier.citationGraf, Nora, and Stephen J. Lippard. “Redox Activation of Metal-Based Prodrugs as a Strategy for Drug Delivery.” Advanced Drug Delivery Reviews 64, no. 11 (August 2012): 993-1004.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.approverLippard, Stephen J.en_US
dc.contributor.mitauthorGraf, Noraen_US
dc.contributor.mitauthorLippard, Stephen J.en_US
dc.relation.journalAdvanced Drug Delivery Reviewsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licensePUBLISHER_CCen_US


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