Blessings in disguise: biological benefits of prion-like mechanisms
Author(s)Newby, Gregory Arthur; Lindquist, Susan
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Prions and amyloids are often associated with disease, but related mechanisms provide beneficial functions in nature. Prion-like mechanisms (PriLiMs) are found from bacteria to humans, where they alter the biological and physical properties of prion-like proteins. We have proposed that prions can serve as heritable bet-hedging devices for diversifying microbial phenotypes. Other, more dynamic proteinaceous complexes may be governed by similar self-templating conformational switches. Additional PriLiMs continue to be identified and many share features of self-templating protein structure (including amyloids) and dependence on chaperone proteins. Here, we discuss several PriLiMs and their functions, intending to spur discussion and collaboration on the subject of beneficial prion-like behaviors.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Trends in Cell Biology
Newby, Gregory A., and Susan Lindquist. “Blessings in Disguise: Biological Benefits of Prion-Like Mechanisms.” Trends in Cell Biology 23, no. 6 (June 2013): 251-259.
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