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dc.contributor.authorHasan, Anwarul
dc.contributor.authorPaul, Arghya
dc.contributor.authorMemic, Adnan
dc.contributor.authorKhademhosseini, Ali
dc.date.accessioned2016-08-25T19:36:22Z
dc.date.available2016-08-25T19:36:22Z
dc.date.issued2015-08
dc.identifier.issn1387-2176
dc.identifier.issn1572-8781
dc.identifier.urihttp://hdl.handle.net/1721.1/103996
dc.description.abstractThere is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. This paper demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like structures on a microfluidic platform using photocrosslinkable gelatin hydrogel. The presented method enables fabrication of physiological blood vessel-like structures with mono-, bi- or tri-layer vascular walls. The diameter of the vessels, the total thickness of the vessel wall and the thickness of each individual layer of the wall were independently controlled. The developed fabrication process is a simple and rapid method, allowing the physical fabrication of the vascular structure in minutes, and the formation of a vascular endothelial cell layer inside the vessels in 3–5 days. The fabricated vascular constructs can potentially be used in numerous applications including drug screening, development of in vitro models for cardiovascular diseases and/or cancer metastasis, and study of vascular biology and mechanobiology.en_US
dc.description.sponsorshipAmerican University of Beirut (startup grant and University Research Board grant)en_US
dc.description.sponsorshipNational Council for Scientific Research (Lebanon)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (EFRI-1240443)en_US
dc.description.sponsorshipImmodgel (602694)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (EB012597, AR057837, DE021468, HL099073, AI105024, AR063745)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.) ( Award Number P20GM103638-04)en_US
dc.description.sponsorshipKing Abdulaziz City for Science and Technology (Grant No. 12-MED3096-3)en_US
dc.publisherSpringer USen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s10544-015-9993-2en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSpringer USen_US
dc.titleA multilayered microfluidic blood vessel-like structureen_US
dc.typeArticleen_US
dc.identifier.citationHasan, Anwarul et al. “A Multilayered Microfluidic Blood Vessel-like Structure.” Biomedical Microdevices 17.5 (2015): n. pag.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorKhademhosseini, Alien_US
dc.contributor.mitauthorHasan, Anwarulen_US
dc.contributor.mitauthorPaul, Arghyaen_US
dc.relation.journalBiomedical Microdevicesen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2016-08-18T15:44:29Z
dc.language.rfc3066en
dc.rights.holderSpringer Science+Business Media New York
dspace.orderedauthorsHasan, Anwarul; Paul, Arghya; Memic, Adnan; Khademhosseini, Alien_US
dspace.embargo.termsNen
mit.licensePUBLISHER_POLICYen_US


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