| dc.contributor.author | Colombe, James Robert | |
| dc.contributor.author | DeBergh, John Robbins | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2016-08-29T15:43:52Z | |
| dc.date.available | 2016-08-29T15:43:52Z | |
| dc.date.issued | 2015-06 | |
| dc.date.submitted | 2015-05 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/104057 | |
| dc.description.abstract | A method for the preparation of aryl and heteroaryl sulfonamides using 2,4,6-trichlorophenyl chlorosulfate (TCPC) is described. The reaction of 2-pyridylzinc reagents with TCPC resulted in 2,4,6-trichlorophenyl (TCP) pyridine-2-sulfonates, and the parent pyridine-2-sulfonate was shown to react with amines. Less electron-rich aryl- and heteroarylzinc reagents reacted with TCPC to afford sulfonyl chlorides that were converted in situ to sulfonamides. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant (GM58160)) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Supplement Award 3-R01-GM046059-20S) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Fellowship (1F32GM099202)) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (NSF Graduate Research Fellowship, Grant 1122374) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/acs.orglett.5b01540 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Colombe, James R., J. Robb DeBergh, and Stephen L. Buchwald. “Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate.” Organic Letters 17, no. 12 (June 19, 2015): 3170–3173. © 2015 American Chemical Society. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Colombe, James Robert | en_US |
| dc.contributor.mitauthor | DeBergh, John Robbins | en_US |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-8750-7968 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
