Show simple item record

dc.contributor.authorLandry, Markita P.
dc.contributor.authorVuković, Lela
dc.contributor.authorKruss, Sebastian
dc.contributor.authorBisker Raviv, Gili Hana
dc.contributor.authorLandry, Alexandra M.
dc.contributor.authorIslam, Shahrin
dc.contributor.authorJain, Rishabh Mahendra
dc.contributor.authorSchulten, Klaus
dc.contributor.authorStrano, Michael S.
dc.date.accessioned2016-08-30T20:34:35Z
dc.date.available2016-08-30T20:34:35Z
dc.date.issued2015-03
dc.date.submitted2015-02
dc.identifier.issn1932-7447
dc.identifier.issn1932-7455
dc.identifier.urihttp://hdl.handle.net/1721.1/104075
dc.description.abstractNoncovalent polymer-single walled carbon nanotube (SWCNT) conjugates have gained recent interest due to their prevalent use as electrochemical and optical sensors, SWCNT-based therapeutics, and for SWCNT separation. However, little is known about the effects of polymer-SWCNT molecular interactions on functional properties of these conjugates. In this work, we show that SWCNT complexed with related polynucleotide polymers (DNA, RNA) have dramatically different fluorescence stability. Surprisingly, we find a difference of nearly 2500-fold in fluorescence emission between the most fluorescently stable DNA-SWCNT complex, C[subscript 30] DNA-SWCNT, compared to the least fluorescently stable complex, (AT)[subscript 7]A-(GU)[subscript 7]G DNA-RNA hybrid-SWCNT. We further reveal the existence of three regimes in which SWCNT fluorescence varies nonmonotonically with SWCNT concentration. We utilize molecular dynamics simulations to elucidate the conformation and atomic details of SWCNT-corona phase interactions. Our results show that variations in polynucleotide sequence or sugar backbone can lead to large changes in the conformational stability of the polymer SWCNT corona and the SWCNT optical response. Finally, we demonstrate the effect of the coronae on the response of a recently developed dopamine nanosensor, based on (GT)[subscript 15] DNA- and (GU)[subscript 15] RNA-SWCNT complexes. Our results clarify several features of the sequence dependence of corona phases produced by polynucleotides adsorbed to single walled carbon nanotubes, and the implications for molecular recognition in such phases.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant NSF-PHY-0822613)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant NSF-PHY1430124)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant NIH 9P41GM104601)en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) (postdoc fellowship)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NSF postdoctoral research fellowship, Award No. 1306229)en_US
dc.description.sponsorshipBurroughs Wellcome Fund (grant, Award No. 1013994)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Award number 1213622)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF Center for the Physics of Living Cells (CPLC) Postdoctoral Fellow)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Cancer Center Support (core) Grant P30-CA14051)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/jp511448een_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleComparative Dynamics and Sequence Dependence of DNA and RNA Binding to Single Walled Carbon Nanotubesen_US
dc.typeArticleen_US
dc.identifier.citationLandry, Markita P., Lela Vuković, Sebastian Kruss, Gili Bisker, Alexandra M. Landry, Shahrin Islam, Rishabh Jain, Klaus Schulten, and Michael S. Strano. "Comparative Dynamics and Sequence Dependence of DNA and RNA Binding to Single Walled Carbon Nanotubes." Journal of Physical Chemistry C 119:18 (March 2015), pp.10048-10058.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorLandry, Markita P.en_US
dc.contributor.mitauthorKruss, Sebastianen_US
dc.contributor.mitauthorBisker Raviv, Gili Hanaen_US
dc.contributor.mitauthorIslam, Shahrinen_US
dc.contributor.mitauthorJain, Rishabh Mahendraen_US
dc.contributor.mitauthorStrano, Michael S.en_US
dc.relation.journalJournal of Physical Chemistry Cen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5832-8522
dc.identifier.orcidhttps://orcid.org/0000-0003-2592-7956
dc.identifier.orcidhttps://orcid.org/0000-0003-2944-808X
mit.licensePUBLISHER_POLICYen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record