Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory
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Author(s)
Bagherzadeh Bioki, Yasaman
Khorrami, Anahita
Zarrindast, Mohammad Reza
Shariat, Seyed Vahid
Pantazis, Dimitrios
Date Issued
February 2016
Journal
Experimental Brain Research
Publisher
Springer Berlin Heidelberg
Citation
Bagherzadeh, Yasaman, Anahita Khorrami, Mohammad Reza Zarrindast, Seyed Vahid Shariat, and Dimitrios Pantazis. “Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex Enhances Working Memory.” Experimental Brain Research 234, no. 7 (February 16, 2016): 1807-1818.
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Author's final manuscript
Abstract
Neuroimaging and electrophysiological studies have unequivocally identified the dorsolateral prefrontal cortex (DLPFC) as a crucial structure for top-down control of working memory (WM) processes. By modulating the excitability of neurons in a targeted cortical area, transcranial magnetic stimulation (TMS) offers a unique way to modulate DLPFC function, opening the possibility of WM facilitation. Even though TMS neuromodulation effects over the left DLPFC have successfully improved WM performance in patients with depression and schizophrenia in a multitude of studies, raising the potential of TMS as a safe efficacious treatment for WM deficits, TMS interventions in healthy individuals have produced mixed and inconclusive results. Here, we stimulated the left DLPFC of healthy individuals using a high-frequency repetitive TMS protocol and evaluated behavioral performance in a battery of cognitive tasks. We found that TMS treatment enhanced WM performance in a verbal digit span and a visuospatial 2-back task.
MIT Department
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s00221-016-4580-1
