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Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1

Author(s)
Boeszoermenyi, Andras; Cheeseman, Iain M; Oberer, Monika; Wagner, Gerhard; Arthanari, Haribabu; Schmidt, Jens Christopher; ... Show more Show less
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Abstract
During mitosis, kinetochores coordinate the attachment of centromeric DNA to the dynamic plus ends of microtubules, which is hypothesized to pull sister chromatids toward opposing poles of the mitotic spindle. The outer kinetochore Ndc80 complex acts synergistically with the Ska (spindle and kinetochore-associated) complex to harness the energy of depolymerizing microtubules and power chromosome movement. The Ska complex is a hexamer consisting of two copies of the proteins Ska1, Ska2 and Ska3, respectively. The C-terminal domain of the spindle and kinetochore-associated protein 1 (Ska1) is the microtubule-binding domain of the Ska complex. We solved the solution structure of the C. elegans microtubule-binding domain (MTBD) of the protein Ska1 using NMR spectroscopy. Here, we report the resonance assignments of the MTBD of C. elegans Ska1.
Date issued
2013-06
URI
http://hdl.handle.net/1721.1/104450
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Biomolecular NMR Assignments
Publisher
Springer Netherlands
Citation
Boeszoermenyi, Andras, Jens C. Schmidt, Iain M. Cheeseman, Monika Oberer, Gerhard Wagner, and Haribabu Arthanari. “Resonance Assignments of the Microtubule-Binding Domain of the C. Elegans Spindle and Kinetochore-Associated Protein 1.” Biomol NMR Assign 8, no. 2 (June 14, 2013): 275–278.
Version: Author's final manuscript
ISSN
1874-2718
1874-270X

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