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dc.contributor.authorHuitfeldt, Anders
dc.contributor.authorKalager, Mette
dc.contributor.authorHoff, Geir
dc.contributor.authorRobins, James M.
dc.contributor.authorHernan, Miguel Angel
dc.date.accessioned2016-10-13T20:23:24Z
dc.date.available2016-10-13T20:23:24Z
dc.date.issued2015-07
dc.identifier.issn2196-2995
dc.identifier.urihttp://hdl.handle.net/1721.1/104806
dc.description.abstractClinical guidelines that rely on observational data due to the absence of data from randomized trials benefit when the observational data or its analysis emulates trial data or its analysis. In this paper, we review a methodology for emulating trials that compare the effects of different timing strategies, that is, strategies that vary the frequency of delivery of a medical intervention or procedure. We review trial emulation for comparing (i) single applications of the procedure at different times, (ii) fixed schedules of application, and (iii) schedules adapted to the evolving clinical characteristics of the patients. For illustration, we describe an application in which we estimate the effect of surveillance colonoscopies in patients who had an adenoma detected during the Norwegian Colorectal Cancer Prevention (NORCCAP) trial.en_US
dc.publisherSpringer International Publishingen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s40471-015-0045-5en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSpringer International Publishingen_US
dc.titleMethods to Estimate the Comparative Effectiveness of Clinical Strategies that Administer the Same Intervention at Different Timesen_US
dc.typeArticleen_US
dc.identifier.citationHuitfeldt, Anders, Mette Kalager, James M. Robins, Geir Hoff, and Miguel A. Hernán. “Methods to Estimate the Comparative Effectiveness of Clinical Strategies That Administer the Same Intervention at Different Times.” Curr Epidemiol Rep 2, no. 3 (July 24, 2015): 149–161.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorHernan, Miguel Angel
dc.relation.journalCurrent Epidemiology Reportsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2016-08-18T15:40:44Z
dc.language.rfc3066en
dc.rights.holderSpringer International Publishing AG
dspace.orderedauthorsHuitfeldt, Anders; Kalager, Mette; Robins, James M.; Hoff, Geir; Hernán, Miguel A.en_US
dspace.embargo.termsNen
mit.licensePUBLISHER_POLICYen_US


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