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Dosage delivery of sensitive reagents enables glove-box-free synthesis

Author(s)
Sather, Aaron C.; Lee, Hong Geun; Colombe, James Robert; Zhang, Anni; Buchwald, Stephen Leffler
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Abstract
Contemporary organic chemists employ a broad range of catalytic and stoichiometric methods to construct molecules for applications in the material sciences, and as pharmaceuticals, agrochemicals, and sensors. The utility of a synthetic method may be greatly reduced if it relies on a glove box to enable the use of air- and moisture-sensitive reagents or catalysts. Furthermore, many synthetic chemistry laboratories have numerous containers of partially used reagents that have been spoiled by exposure to the ambient atmosphere. This is exceptionally wasteful from both an environmental and a cost perspective. Here we report an encapsulation method for stabilizing and storing air- and moisture-sensitive compounds. We demonstrate this approach in three contexts, by describing single-use capsules that contain all of the reagents (catalysts, ligands, and bases) necessary for the glove-box-free palladium-catalysed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond-forming reactions. This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedures required for such syntheses and should be applicable to a wide range of reagents, catalysts, and substrate combinations.
Date issued
2015-08
URI
http://hdl.handle.net/1721.1/104849
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Nature
Publisher
Springer Nature
Citation
Sather, Aaron C., Hong Geun Lee, James R. Colombe, Anni Zhang, and Stephen L. Buchwald. “Dosage Delivery of Sensitive Reagents Enables Glove-Box-Free Synthesis.” Nature 524, no. 7564 (August 12, 2015): 208–211. © 2015 Nature Publishing Group.
Version: Final published version
ISSN
0028-0836
1476-4687

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