Antiviral and Antibacterial Polyurethanes of Various Modalities

Author(s)
Park, Daewon; Wang, Yadong; Larson, Alyssa Maxine; Klibanov, Alexander M
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Abstract
We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).
Date issued
2013-01
URI
http://hdl.handle.net/1721.1/105862
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemistry
Journal
Applied Biochemistry and Biotechnology
Publisher
Springer-Verlag
Citation
Park, Daewon, Alyssa M. Larson, Alexander M. Klibanov, and Yadong Wang. “Antiviral and Antibacterial Polyurethanes of Various Modalities.” Applied Biochemistry and Biotechnology 169, no. 4 (January 10, 2013): 1134–1146.
Version: Author's final manuscript
ISSN
0273-2289
1559-0291
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