dc.contributor.author | Abeshouse, Adam | |
dc.contributor.author | Ahn, Jaeil | |
dc.contributor.author | Akbani, Rehan | |
dc.contributor.author | Ally, Adrian | |
dc.contributor.author | Amin, Samirkumar | |
dc.contributor.author | Andry, Christopher D. | |
dc.contributor.author | Annala, Matti | |
dc.contributor.author | Aprikian, Armen | |
dc.contributor.author | Armenia, Joshua | |
dc.contributor.author | Arora, Arshi | |
dc.contributor.author | Auman, J. Todd | |
dc.contributor.author | Balasundaram, Miruna | |
dc.contributor.author | Balu, Saianand | |
dc.contributor.author | Barbieri, Christopher E. | |
dc.contributor.author | Bauer, Thomas | |
dc.contributor.author | Benz, Christopher C. | |
dc.contributor.author | Bergeron, Alain | |
dc.contributor.author | Beroukhim, Rameen | |
dc.contributor.author | Berrios, Mario | |
dc.contributor.author | Bivol, Adrian | |
dc.contributor.author | Bodenheimer, Tom | |
dc.contributor.author | Boice, Lori | |
dc.contributor.author | Bootwalla, Moiz S. | |
dc.contributor.author | dos Reis, Rodolfo Borges | |
dc.contributor.author | Boutros, Paul C. | |
dc.contributor.author | Bowen, Jay | |
dc.contributor.author | Bowlby, Reanne | |
dc.contributor.author | Boyd, Jeffrey | |
dc.contributor.author | Breggia, Anne | |
dc.contributor.author | Brimo, Fadi | |
dc.contributor.author | Brooks, Denise | |
dc.contributor.author | Broom, Bradley M. | |
dc.contributor.author | Bryce, Alan H. | |
dc.contributor.author | Bubley, Glenn | |
dc.contributor.author | Burks, Eric | |
dc.contributor.author | Butterfield, Yaron S.N. | |
dc.contributor.author | Button, Michael | |
dc.contributor.author | Canes, David | |
dc.contributor.author | Carlotti, Carlos G. | |
dc.contributor.author | Carlsen, Rebecca | |
dc.contributor.author | Carroll, Peter R. | |
dc.contributor.author | Cartun, Richard | |
dc.contributor.author | Carver, Brett S. | |
dc.contributor.author | Chan, June M. | |
dc.contributor.author | Chang, Matthew T. | |
dc.contributor.author | Chen, Yu | |
dc.contributor.author | Costello, Anthony J. | |
dc.contributor.author | Cherniack, Andrew D. | |
dc.contributor.author | Chevalier, Simone | |
dc.contributor.author | Cho, Juok | |
dc.contributor.author | Chu, Andy | |
dc.contributor.author | Chuah, Eric | |
dc.contributor.author | Chudamani, Sudha | |
dc.contributor.author | Ciriello, Giovanni | |
dc.contributor.author | Clarke, Amanda | |
dc.contributor.author | Cooperberg, Matthew R. | |
dc.contributor.author | Corcoran, Niall M. | |
dc.contributor.author | Cowan, Janet | |
dc.contributor.author | Crain, Daniel | |
dc.contributor.author | Curley, Erin | |
dc.contributor.author | David, Kerstin | |
dc.contributor.author | Demchok, John A. | |
dc.contributor.author | Demichelis, Francesca | |
dc.contributor.author | Dhalla, Noreen | |
dc.contributor.author | Dhir, Rajiv | |
dc.contributor.author | Doueik, Alexandre | |
dc.contributor.author | Drake, Bettina | |
dc.contributor.author | Dvinge, Heidi | |
dc.contributor.author | Dyakova, Natalya | |
dc.contributor.author | Felau, Ina | |
dc.contributor.author | Ferguson, Martin L. | |
dc.contributor.author | Frazer, Scott | |
dc.contributor.author | Freedland, Stephen | |
dc.contributor.author | Fu, Yao | |
dc.contributor.author | Bristow, Christopher A. | |
dc.contributor.author | Gao, Jianjiong | |
dc.contributor.author | Gardner, Johanna | |
dc.contributor.author | Gastier-Foster, Julie M. | |
dc.contributor.author | Gehlenborg, Nils | |
dc.contributor.author | Gerken, Mark | |
dc.contributor.author | Gerstein, Mark B. | |
dc.contributor.author | Godwin, Andrew K. | |
dc.contributor.author | Gopalan, Anuradha | |
dc.contributor.author | Graefen, Markus | |
dc.contributor.author | Graim, Kiley | |
dc.contributor.author | Gribbin, Thomas | |
dc.contributor.author | Guin, Ranabir | |
dc.contributor.author | Gupta, Manaswi | |
dc.contributor.author | Hadjipanayis, Angela | |
dc.contributor.author | Haider, Syed | |
dc.contributor.author | Hamel, Lucie | |
dc.contributor.author | Hayes, D. Neil | |
dc.contributor.author | Hess, Julian | |
dc.contributor.author | Hoadley, Katherine A. | |
dc.contributor.author | Holbrook, Andrea H. | |
dc.contributor.author | Holt, Robert A. | |
dc.contributor.author | Holway, Antonia | |
dc.contributor.author | Hovens, Christopher M. | |
dc.contributor.author | Hoyle, Alan P. | |
dc.contributor.author | Huang, Mei | |
dc.contributor.author | Hutter, Carolyn M. | |
dc.contributor.author | Ittmann, Michael | |
dc.contributor.author | Iype, Lisa | |
dc.contributor.author | Jefferys, Stuart R. | |
dc.contributor.author | Jones, Corbin D. | |
dc.contributor.author | Jones, Steven J.M. | |
dc.contributor.author | Juhl, Hartmut | |
dc.contributor.author | Kahles, Andre | |
dc.contributor.author | Kane, Christopher J. | |
dc.contributor.author | Kasaian, Katayoon | |
dc.contributor.author | Kerger, Michael | |
dc.contributor.author | Khurana, Ekta | |
dc.contributor.author | Kim, Jaegil | |
dc.contributor.author | Klein, Robert J. | |
dc.contributor.author | Kucherlapati, Raju | |
dc.contributor.author | Lacombe, Louis | |
dc.contributor.author | Ladanyi, Marc | |
dc.contributor.author | Lai, Phillip H. | |
dc.contributor.author | Laird, Peter W. | |
dc.contributor.author | Latour, Mathieu | |
dc.contributor.author | Lawrence, Michael S. | |
dc.contributor.author | Lau, Kevin | |
dc.contributor.author | LeBien, Tucker | |
dc.contributor.author | Lee, Darlene | |
dc.contributor.author | Lee, Semin | |
dc.contributor.author | Lehmann, Kjong-Van | |
dc.contributor.author | Leraas, Kristen M. | |
dc.contributor.author | Leshchiner, Ignaty | |
dc.contributor.author | Leung, Robert | |
dc.contributor.author | Libertino, John A. | |
dc.contributor.author | Lichtenberg, Tara M. | |
dc.contributor.author | Linehan, W. Marston | |
dc.contributor.author | Ling, Shiyun | |
dc.contributor.author | Lippman, Scott M. | |
dc.contributor.author | Liu, Jia | |
dc.contributor.author | Liu, Wenbin | |
dc.contributor.author | Lochovsky, Lucas | |
dc.contributor.author | Logothetis, Christopher | |
dc.contributor.author | Lolla, Laxmi | |
dc.contributor.author | Longacre, Teri | |
dc.contributor.author | Lu, Yiling | |
dc.contributor.author | Luo, Jianhua | |
dc.contributor.author | Ma, Yussanne | |
dc.contributor.author | Mahadeshwar, Harshad S. | |
dc.contributor.author | Mallery, David | |
dc.contributor.author | Mariamidze, Armaz | |
dc.contributor.author | Marra, Marco A. | |
dc.contributor.author | Mayo, Michael | |
dc.contributor.author | McCall, Shannon | |
dc.contributor.author | McKercher, Ginette | |
dc.contributor.author | Meng, Shaowu | |
dc.contributor.author | Mes-Masson, Anne-Marie | |
dc.contributor.author | Merino, Maria J. | |
dc.contributor.author | Mieczkowski, Piotr A. | |
dc.contributor.author | Mills, Gordon B. | |
dc.contributor.author | Mills Shaw, Kenna R. | |
dc.contributor.author | Minner, Sarah | |
dc.contributor.author | Moinzadeh, Alireza | |
dc.contributor.author | Moore, Richard A. | |
dc.contributor.author | Morris, Scott | |
dc.contributor.author | Morrison, Carl | |
dc.contributor.author | Mose, Lisle E. | |
dc.contributor.author | Mungall, Andrew J. | |
dc.contributor.author | Murray, Bradley A. | |
dc.contributor.author | Myers, Jerome B. | |
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dc.contributor.author | Nelson, Joel | |
dc.contributor.author | Nelson, Mark A. | |
dc.contributor.author | Nelson, Peter S. | |
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dc.contributor.author | Noble, Michael S. | |
dc.contributor.author | Noushmehr, Houtan | |
dc.contributor.author | Nykter, Matti | |
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dc.contributor.author | Parfenov, Michael | |
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dc.contributor.author | Paulauskis, Joseph | |
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dc.contributor.author | Scarlata, Eleonora | |
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dc.contributor.author | Schlomm, Thorsten | |
dc.contributor.author | Schmidt, Laura S. | |
dc.contributor.author | Schultz, Nikolaus | |
dc.contributor.author | Schumacher, Steven E. | |
dc.contributor.author | Neder, Luciano | |
dc.contributor.author | Seth, Sahil | |
dc.contributor.author | Sharp, Alexis | |
dc.contributor.author | Shelton, Candace | |
dc.contributor.author | Shelton, Troy | |
dc.contributor.author | Shen, Hui | |
dc.contributor.author | Shen, Ronglai | |
dc.contributor.author | Sherman, Mark | |
dc.contributor.author | Sheth, Margi | |
dc.contributor.author | Shi, Yan | |
dc.contributor.author | Shih, Juliann | |
dc.contributor.author | Shmulevich, Ilya | |
dc.contributor.author | Simko, Jeffry | |
dc.contributor.author | Simon, Ronald | |
dc.contributor.author | Simons, Janae V. | |
dc.contributor.author | Sipahimalani, Payal | |
dc.contributor.author | Skelly, Tara | |
dc.contributor.author | Sofia, Heidi J. | |
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dc.contributor.author | Sorcini, Andrea | |
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dc.contributor.author | Weinhold, Nils | |
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dc.contributor.author | Weisenberger, Daniel J. | |
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dc.contributor.author | Wise, Lisa | |
dc.contributor.author | Witte, John | |
dc.contributor.author | Wu, Chia-Chin | |
dc.contributor.author | Wu, Junyuan | |
dc.contributor.author | Wu, Ye | |
dc.contributor.author | Xu, Andrew W. | |
dc.contributor.author | Yadav, Shalini S. | |
dc.contributor.author | Yang, Liming | |
dc.contributor.author | Yang, Lixing | |
dc.contributor.author | Yau, Christina | |
dc.contributor.author | Ye, Huihui | |
dc.contributor.author | Yena, Peggy | |
dc.contributor.author | Zeng, Thomas | |
dc.contributor.author | Zenklusen, Jean C. | |
dc.contributor.author | Zhang, Hailei | |
dc.contributor.author | Zhang, Jiashan | |
dc.contributor.author | Zhang, Wei | |
dc.contributor.author | Zhong, Yi | |
dc.contributor.author | Zhu, Kelsey | |
dc.contributor.author | Zmuda, Erik | |
dc.contributor.author | Cancer Genome Atlas Research Network | |
dc.contributor.author | Carmell, Michelle | |
dc.contributor.author | Carter, Scott | |
dc.contributor.author | Chin, Lynda | |
dc.contributor.author | Cibulskis, Kristian | |
dc.contributor.author | Getz, Gad Asher | |
dc.contributor.author | Heiman, David | |
dc.contributor.author | Lander, Eric Steven | |
dc.contributor.author | Lin, Pei | |
dc.contributor.author | Loda, Massimo | |
dc.contributor.author | Seidman, Jonathan | |
dc.contributor.author | Sougnez, Carrie L | |
dc.contributor.author | Verhaak, Roel | |
dc.contributor.author | Voet, Douglas | |
dc.contributor.author | Bradley, Robert K. | |
dc.contributor.author | Meyerson, Matthew L. | |
dc.contributor.author | Park, Peter J. | |
dc.date.accessioned | 2017-01-09T20:48:03Z | |
dc.date.available | 2017-01-09T20:48:03Z | |
dc.date.issued | 2015-11 | |
dc.date.submitted | 2015-08 | |
dc.identifier.issn | 00928674 | |
dc.identifier.issn | 10974172 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/106307 | |
dc.description.abstract | There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143799) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143835) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143840) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143843) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143845) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143848) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143858) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143866) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143867) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143882) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA143883) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant 5U24CA144025) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant U54HG003067) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant U54HG003079) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant U54HG003273) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). (grant P30CA16672) | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2015.10.025 | en_US |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | The Molecular Taxonomy of Primary Prostate Cancer | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Abeshouse, Adam, et al. “The Molecular Taxonomy of Primary Prostate Cancer.” Cell, vol. 163, no. 4, 2015, pp. 1011–1025. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Broad Institute of MIT and Harvard | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.mitauthor | Bradley, Robert K | |
dc.contributor.mitauthor | Carmell, Michelle | |
dc.contributor.mitauthor | Carter, Scott | |
dc.contributor.mitauthor | Chin, Lynda | |
dc.contributor.mitauthor | Cibulskis, Kristian | |
dc.contributor.mitauthor | Getz, Gad Asher | |
dc.contributor.mitauthor | Heiman, David | |
dc.contributor.mitauthor | Lander, Eric Steven | |
dc.contributor.mitauthor | Lin, Pei | |
dc.contributor.mitauthor | Loda, Massimo | |
dc.contributor.mitauthor | Meyerson, Matthew L | |
dc.contributor.mitauthor | Park, Peter J | |
dc.contributor.mitauthor | Seidman, Jonathan | |
dc.contributor.mitauthor | Sougnez, Carrie L | |
dc.contributor.mitauthor | Verhaak, Roel | |
dc.contributor.mitauthor | Voet, Douglas | |
dc.relation.journal | Cell | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8046-1063 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |