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dc.contributor.authorAbeshouse, Adam
dc.contributor.authorAhn, Jaeil
dc.contributor.authorAkbani, Rehan
dc.contributor.authorAlly, Adrian
dc.contributor.authorAmin, Samirkumar
dc.contributor.authorAndry, Christopher D.
dc.contributor.authorAnnala, Matti
dc.contributor.authorAprikian, Armen
dc.contributor.authorArmenia, Joshua
dc.contributor.authorArora, Arshi
dc.contributor.authorAuman, J. Todd
dc.contributor.authorBalasundaram, Miruna
dc.contributor.authorBalu, Saianand
dc.contributor.authorBarbieri, Christopher E.
dc.contributor.authorBauer, Thomas
dc.contributor.authorBenz, Christopher C.
dc.contributor.authorBergeron, Alain
dc.contributor.authorBeroukhim, Rameen
dc.contributor.authorBerrios, Mario
dc.contributor.authorBivol, Adrian
dc.contributor.authorBodenheimer, Tom
dc.contributor.authorBoice, Lori
dc.contributor.authorBootwalla, Moiz S.
dc.contributor.authordos Reis, Rodolfo Borges
dc.contributor.authorBoutros, Paul C.
dc.contributor.authorBowen, Jay
dc.contributor.authorBowlby, Reanne
dc.contributor.authorBoyd, Jeffrey
dc.contributor.authorBreggia, Anne
dc.contributor.authorBrimo, Fadi
dc.contributor.authorBrooks, Denise
dc.contributor.authorBroom, Bradley M.
dc.contributor.authorBryce, Alan H.
dc.contributor.authorBubley, Glenn
dc.contributor.authorBurks, Eric
dc.contributor.authorButterfield, Yaron S.N.
dc.contributor.authorButton, Michael
dc.contributor.authorCanes, David
dc.contributor.authorCarlotti, Carlos G.
dc.contributor.authorCarlsen, Rebecca
dc.contributor.authorCarroll, Peter R.
dc.contributor.authorCartun, Richard
dc.contributor.authorCarver, Brett S.
dc.contributor.authorChan, June M.
dc.contributor.authorChang, Matthew T.
dc.contributor.authorChen, Yu
dc.contributor.authorCostello, Anthony J.
dc.contributor.authorCherniack, Andrew D.
dc.contributor.authorChevalier, Simone
dc.contributor.authorCho, Juok
dc.contributor.authorChu, Andy
dc.contributor.authorChuah, Eric
dc.contributor.authorChudamani, Sudha
dc.contributor.authorCiriello, Giovanni
dc.contributor.authorClarke, Amanda
dc.contributor.authorCooperberg, Matthew R.
dc.contributor.authorCorcoran, Niall M.
dc.contributor.authorCowan, Janet
dc.contributor.authorCrain, Daniel
dc.contributor.authorCurley, Erin
dc.contributor.authorDavid, Kerstin
dc.contributor.authorDemchok, John A.
dc.contributor.authorDemichelis, Francesca
dc.contributor.authorDhalla, Noreen
dc.contributor.authorDhir, Rajiv
dc.contributor.authorDoueik, Alexandre
dc.contributor.authorDrake, Bettina
dc.contributor.authorDvinge, Heidi
dc.contributor.authorDyakova, Natalya
dc.contributor.authorFelau, Ina
dc.contributor.authorFerguson, Martin L.
dc.contributor.authorFrazer, Scott
dc.contributor.authorFreedland, Stephen
dc.contributor.authorFu, Yao
dc.contributor.authorBristow, Christopher A.
dc.contributor.authorGao, Jianjiong
dc.contributor.authorGardner, Johanna
dc.contributor.authorGastier-Foster, Julie M.
dc.contributor.authorGehlenborg, Nils
dc.contributor.authorGerken, Mark
dc.contributor.authorGerstein, Mark B.
dc.contributor.authorGodwin, Andrew K.
dc.contributor.authorGopalan, Anuradha
dc.contributor.authorGraefen, Markus
dc.contributor.authorGraim, Kiley
dc.contributor.authorGribbin, Thomas
dc.contributor.authorGuin, Ranabir
dc.contributor.authorGupta, Manaswi
dc.contributor.authorHadjipanayis, Angela
dc.contributor.authorHaider, Syed
dc.contributor.authorHamel, Lucie
dc.contributor.authorHayes, D. Neil
dc.contributor.authorHess, Julian
dc.contributor.authorHoadley, Katherine A.
dc.contributor.authorHolbrook, Andrea H.
dc.contributor.authorHolt, Robert A.
dc.contributor.authorHolway, Antonia
dc.contributor.authorHovens, Christopher M.
dc.contributor.authorHoyle, Alan P.
dc.contributor.authorHuang, Mei
dc.contributor.authorHutter, Carolyn M.
dc.contributor.authorIttmann, Michael
dc.contributor.authorIype, Lisa
dc.contributor.authorJefferys, Stuart R.
dc.contributor.authorJones, Corbin D.
dc.contributor.authorJones, Steven J.M.
dc.contributor.authorJuhl, Hartmut
dc.contributor.authorKahles, Andre
dc.contributor.authorKane, Christopher J.
dc.contributor.authorKasaian, Katayoon
dc.contributor.authorKerger, Michael
dc.contributor.authorKhurana, Ekta
dc.contributor.authorKim, Jaegil
dc.contributor.authorKlein, Robert J.
dc.contributor.authorKucherlapati, Raju
dc.contributor.authorLacombe, Louis
dc.contributor.authorLadanyi, Marc
dc.contributor.authorLai, Phillip H.
dc.contributor.authorLaird, Peter W.
dc.contributor.authorLatour, Mathieu
dc.contributor.authorLawrence, Michael S.
dc.contributor.authorLau, Kevin
dc.contributor.authorLeBien, Tucker
dc.contributor.authorLee, Darlene
dc.contributor.authorLee, Semin
dc.contributor.authorLehmann, Kjong-Van
dc.contributor.authorLeraas, Kristen M.
dc.contributor.authorLeshchiner, Ignaty
dc.contributor.authorLeung, Robert
dc.contributor.authorLibertino, John A.
dc.contributor.authorLichtenberg, Tara M.
dc.contributor.authorLinehan, W. Marston
dc.contributor.authorLing, Shiyun
dc.contributor.authorLippman, Scott M.
dc.contributor.authorLiu, Jia
dc.contributor.authorLiu, Wenbin
dc.contributor.authorLochovsky, Lucas
dc.contributor.authorLogothetis, Christopher
dc.contributor.authorLolla, Laxmi
dc.contributor.authorLongacre, Teri
dc.contributor.authorLu, Yiling
dc.contributor.authorLuo, Jianhua
dc.contributor.authorMa, Yussanne
dc.contributor.authorMahadeshwar, Harshad S.
dc.contributor.authorMallery, David
dc.contributor.authorMariamidze, Armaz
dc.contributor.authorMarra, Marco A.
dc.contributor.authorMayo, Michael
dc.contributor.authorMcCall, Shannon
dc.contributor.authorMcKercher, Ginette
dc.contributor.authorMeng, Shaowu
dc.contributor.authorMes-Masson, Anne-Marie
dc.contributor.authorMerino, Maria J.
dc.contributor.authorMieczkowski, Piotr A.
dc.contributor.authorMills, Gordon B.
dc.contributor.authorMills Shaw, Kenna R.
dc.contributor.authorMinner, Sarah
dc.contributor.authorMoinzadeh, Alireza
dc.contributor.authorMoore, Richard A.
dc.contributor.authorMorris, Scott
dc.contributor.authorMorrison, Carl
dc.contributor.authorMose, Lisle E.
dc.contributor.authorMungall, Andrew J.
dc.contributor.authorMurray, Bradley A.
dc.contributor.authorMyers, Jerome B.
dc.contributor.authorNaresh, Rashi
dc.contributor.authorNelson, Joel
dc.contributor.authorNelson, Mark A.
dc.contributor.authorNelson, Peter S.
dc.contributor.authorNewton, Yulia
dc.contributor.authorNoble, Michael S.
dc.contributor.authorNoushmehr, Houtan
dc.contributor.authorNykter, Matti
dc.contributor.authorPantazi, Angeliki
dc.contributor.authorParfenov, Michael
dc.contributor.authorParker, Joel S.
dc.contributor.authorPaulauskis, Joseph
dc.contributor.authorPenny, Robert
dc.contributor.authorPerou, Charles M.
dc.contributor.authorPiche, Alain
dc.contributor.authorPihl, Todd
dc.contributor.authorPinto, Peter A.
dc.contributor.authorPrandi, Davide
dc.contributor.authorProtopopov, Alexei
dc.contributor.authorRamirez, Nilsa C.
dc.contributor.authorRao, Arvind
dc.contributor.authorRathmell, W. Kimryn
dc.contributor.authorRatsch, Gunnar
dc.contributor.authorRen, Xiaojia
dc.contributor.authorReuter, Victor E.
dc.contributor.authorReynolds, Sheila M.
dc.contributor.authorRhie, Suhn K.
dc.contributor.authorRieger-Christ, Kimberly
dc.contributor.authorRoach, Jeffrey
dc.contributor.authorRobertson, A. Gordon
dc.contributor.authorRobinson, Brian
dc.contributor.authorRubin, Mark A.
dc.contributor.authorSaad, Fred
dc.contributor.authorSadeghi, Sara
dc.contributor.authorSaksena, Gordon
dc.contributor.authorSaller, Charles
dc.contributor.authorSalner, Andrew
dc.contributor.authorSanchez-Vega, Francisco
dc.contributor.authorSander, Chris
dc.contributor.authorSandusky, George
dc.contributor.authorSauter, Guido
dc.contributor.authorSboner, Andrea
dc.contributor.authorScardino, Peter T.
dc.contributor.authorScarlata, Eleonora
dc.contributor.authorSchein, Jacqueline E.
dc.contributor.authorSchlomm, Thorsten
dc.contributor.authorSchmidt, Laura S.
dc.contributor.authorSchultz, Nikolaus
dc.contributor.authorSchumacher, Steven E.
dc.contributor.authorNeder, Luciano
dc.contributor.authorSeth, Sahil
dc.contributor.authorSharp, Alexis
dc.contributor.authorShelton, Candace
dc.contributor.authorShelton, Troy
dc.contributor.authorShen, Hui
dc.contributor.authorShen, Ronglai
dc.contributor.authorSherman, Mark
dc.contributor.authorSheth, Margi
dc.contributor.authorShi, Yan
dc.contributor.authorShih, Juliann
dc.contributor.authorShmulevich, Ilya
dc.contributor.authorSimko, Jeffry
dc.contributor.authorSimon, Ronald
dc.contributor.authorSimons, Janae V.
dc.contributor.authorSipahimalani, Payal
dc.contributor.authorSkelly, Tara
dc.contributor.authorSofia, Heidi J.
dc.contributor.authorSoloway, Matthew G.
dc.contributor.authorSong, Xingzhi
dc.contributor.authorSorcini, Andrea
dc.contributor.authorStepa, Serghei
dc.contributor.authorStewart, Chip
dc.contributor.authorStewart, John
dc.contributor.authorStuart, Joshua M.
dc.contributor.authorSullivan, Travis B.
dc.contributor.authorSun, Charlie
dc.contributor.authorSun, Huandong
dc.contributor.authorTam, Angela
dc.contributor.authorTan, Donghui
dc.contributor.authorTang, Jiabin
dc.contributor.authorTarnuzzer, Roy
dc.contributor.authorTarvin, Katherine
dc.contributor.authorTaylor, Barry S.
dc.contributor.authorTeebagy, Patrick
dc.contributor.authorTenggara, Imelda
dc.contributor.authorTetu, Bernard
dc.contributor.authorTewari, Ashutosh
dc.contributor.authorThiessen, Nina
dc.contributor.authorThompson, Timothy
dc.contributor.authorThorne, Leigh B.
dc.contributor.authorTirapelli, Daniela P.
dc.contributor.authorTomlins, Scott A.
dc.contributor.authorTrevisan, Felipe Amstalden
dc.contributor.authorTroncoso, Patricia
dc.contributor.authorTrue, Lawrence D.
dc.contributor.authorTsourlakis, Maria Christina
dc.contributor.authorTyekucheva, Svitlana
dc.contributor.authorVan Allen, Eliezer
dc.contributor.authorVan Den Berg, David J.
dc.contributor.authorVeluvolu, Umadevi
dc.contributor.authorVocke, Cathy D.
dc.contributor.authorWan, Yunhu
dc.contributor.authorWang, Qingguo
dc.contributor.authorWang, Wenyi
dc.contributor.authorWang, Zhining
dc.contributor.authorWeinhold, Nils
dc.contributor.authorWeinstein, John N.
dc.contributor.authorWeisenberger, Daniel J.
dc.contributor.authorWilkerson, Matthew D.
dc.contributor.authorWise, Lisa
dc.contributor.authorWitte, John
dc.contributor.authorWu, Chia-Chin
dc.contributor.authorWu, Junyuan
dc.contributor.authorWu, Ye
dc.contributor.authorXu, Andrew W.
dc.contributor.authorYadav, Shalini S.
dc.contributor.authorYang, Liming
dc.contributor.authorYang, Lixing
dc.contributor.authorYau, Christina
dc.contributor.authorYe, Huihui
dc.contributor.authorYena, Peggy
dc.contributor.authorZeng, Thomas
dc.contributor.authorZenklusen, Jean C.
dc.contributor.authorZhang, Hailei
dc.contributor.authorZhang, Jiashan
dc.contributor.authorZhang, Wei
dc.contributor.authorZhong, Yi
dc.contributor.authorZhu, Kelsey
dc.contributor.authorZmuda, Erik
dc.contributor.authorCancer Genome Atlas Research Network
dc.contributor.authorCarmell, Michelle
dc.contributor.authorCarter, Scott
dc.contributor.authorChin, Lynda
dc.contributor.authorCibulskis, Kristian
dc.contributor.authorGetz, Gad Asher
dc.contributor.authorHeiman, David
dc.contributor.authorLander, Eric Steven
dc.contributor.authorLin, Pei
dc.contributor.authorLoda, Massimo
dc.contributor.authorSeidman, Jonathan
dc.contributor.authorSougnez, Carrie L
dc.contributor.authorVerhaak, Roel
dc.contributor.authorVoet, Douglas
dc.contributor.authorBradley, Robert K.
dc.contributor.authorMeyerson, Matthew L.
dc.contributor.authorPark, Peter J.
dc.date.accessioned2017-01-09T20:48:03Z
dc.date.available2017-01-09T20:48:03Z
dc.date.issued2015-11
dc.date.submitted2015-08
dc.identifier.issn00928674
dc.identifier.issn10974172
dc.identifier.urihttp://hdl.handle.net/1721.1/106307
dc.description.abstractThere is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143799)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143835)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143840)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143843)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143845)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143848)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143858)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143866)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143867)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143882)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA143883)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant 5U24CA144025)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant U54HG003067)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant U54HG003079)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant U54HG003273)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). (grant P30CA16672)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2015.10.025en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleThe Molecular Taxonomy of Primary Prostate Canceren_US
dc.typeArticleen_US
dc.identifier.citationAbeshouse, Adam, et al. “The Molecular Taxonomy of Primary Prostate Cancer.” Cell, vol. 163, no. 4, 2015, pp. 1011–1025.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentBroad Institute of MIT and Harvarden_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorBradley, Robert K
dc.contributor.mitauthorCarmell, Michelle
dc.contributor.mitauthorCarter, Scott
dc.contributor.mitauthorChin, Lynda
dc.contributor.mitauthorCibulskis, Kristian
dc.contributor.mitauthorGetz, Gad Asher
dc.contributor.mitauthorHeiman, David
dc.contributor.mitauthorLander, Eric Steven
dc.contributor.mitauthorLin, Pei
dc.contributor.mitauthorLoda, Massimo
dc.contributor.mitauthorMeyerson, Matthew L
dc.contributor.mitauthorPark, Peter J
dc.contributor.mitauthorSeidman, Jonathan
dc.contributor.mitauthorSougnez, Carrie L
dc.contributor.mitauthorVerhaak, Roel
dc.contributor.mitauthorVoet, Douglas
dc.relation.journalCellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8046-1063
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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