MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Host AMPK Is a Modulator of Plasmodium Liver Infection

Author(s)
Ruivo, Margarida T. Grilo; Vera, Iset Medina; Sales-Dias, Joana; Meireles, Patrícia; Mota, Maria M.; Mancio-Silva, Liliana; Gural, Nil; Bhatia, Sangeeta N; ... Show more Show less
Thumbnail
DownloadRuivo-2016-Host AMPK Is a Modul.pdf (1.692Mb)
PUBLISHER_CC

Publisher with Creative Commons License

Creative Commons Attribution

Terms of use
Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/
Metadata
Show full item record
Abstract
Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here, we demonstrate that the opposite is observed in cells infected with rodent malaria parasites. Indeed, AMPK activity upon the infection of hepatic cells is suppressed and dispensable for successful infection. By contrast, an overactive AMPK is deleterious to intracellular growth and replication of different Plasmodium spp., including the human malaria parasite, P. falciparum. The negative impact of host AMPK activity on infection was further confirmed in mice under conditions that activate its function. Overall, this work establishes the role of host AMPK signaling as a suppressive pathway of Plasmodium hepatic infection and as a potential target for host-based antimalarial interventions.
Date issued
2016-08
URI
http://hdl.handle.net/1721.1/106319
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
Cell Reports
Publisher
Elsevier
Citation
Ruivo, Margarida T. Grilo et al. “Host AMPK Is a Modulator of Plasmodium Liver Infection.” Cell Reports 16.10 (2016): 2539–2545.
Version: Final published version
ISSN
22111247

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.